Gene Mb0876c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepdc
Gene length1683 bp
IdentifierMb0876c
Location 950191 bp
Protein summary information
Molecular mass59783.1 Da
Isoelectric point5.0798
Protein length560 amino acids
Orthologs
M. tuberculosis H37RvRv0853c
M. tuberculosis MTBC0mtbc0_000908
Cross-references
UniProtQ7U140
UniProtKB/TrEMBLX2BGC9, Q7U140
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE PYRUVATE OR INDOLE-3-PYRUVATE DECARBOXYLASE PDC
CommentsMb0876c, pdc, len: 560 aa. Equivalent to Rv0853c,len: 560 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 560 aa overlap). Probable pdc,pyruvate or indole-pyruvate decarboxylase (EC 4.1.1.-),equivalent to NP_302424.1|NC_002677 pyruvate (or indolepyruvate) decarboxylase from Mycobacterium leprae (569 aa). Also highly similar to others e.g. AAB06571.1|L80006 indolepyruvate decarboxylase from Pantoea agglomerans (550 aa); Q12629|DCPY_KLULA PYRUVATE DECARBOXYLASE (EC 4.1.1.1) from Kluyveromyces marxianus var. lactis (563 aa); P71323 INDOLEPYRUVATE DECARBOXYLASE (EC 4.1.1.74) from Enterobacter herbicola (550 aa), FASTA scores: opt: 1642, E(): 0, (48.1% identity in 547 aa overlap); P23234|DCIP_ENTCL INDOLE-3-PYRUVATE DECARBOXYLASE (INDOLEPYRUVATE DECARBOXYLASE) from Enterobacter cloacae (552 aa), FASTA scores: opt: 1596,E(): 0, (46.8% identity in 551 aa overlap); etc. Contains PS00187 Thiamine pyrophosphate enzymes signature and PS00017 ATP/GTP-binding site motif A (P-loop). COFACTOR: THIAMINE PYROPHOSPHATE.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS950191951873-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0876c|pdc
MTPQKSDACSDPVYTVGDYLLDRLAELGVSEIFGVPGDYNLQFLDHIVAHPTIRWVGSANELNAGYAADGYGRLRGMSAVVTTFGVGELSVTNAIAGSYAEHVPVVHIVGGPTKDAQGTRRALHHSLGDGDFEHFLRISREITCAQANLMPATAGREIDRVLSEVREQKRPGYILLSSDVARFPTEPPAAPLPRYPGGTSPRALSLFTKAAIELIADHQLTVLADLLVHRLQAVKELEALLAADVVPHATLMWGKSLLDESSPNFLGIYAGAASAERVRAAIEGAPVLVTAGVVFTDMVSGFFSQRIDPARTIDIGQYQSSVADQVFAPLEMSAALQALATILTGRGISSPPVVPPPAEPPPAMPARDEPLTQQMVWDRVCSALTPGNVVLADQGTSFYGMADHRLPQGVTFIGQPLWGSIGYTLPAAVGAAVAHPDRRTVLLIGDGAAQLTVQELGTFSREGLSPVIVVVNNDGYTVERAIHGETAPYNDIVSWNWTELPSALGVTNHLAFRAQTYGQLDDALTVAAARRDRMVLVEVVLPRLEIPRLLGQLVGSMAPQ
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