Gene Mb1038 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameispE
Gene length921 bp
IdentifierMb1038
Location 1130642 bp
Protein summary information
Molecular mass31381.7 Da
Isoelectric point4.5351
Protein length306 amino acids
Orthologs
M. tuberculosis MTBC0mtbc0_001086
M. tuberculosis H37RvRv1011
Cross-references
UniProtP65179
UniProtKB/TrEMBLX2BGV6, P65179
General annotation
TypeCDS
FunctionUnknown
ProductProbable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ISPE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase)
CommentsMb1038, ispE, len: 306 aa. Equivalent to Rv1011,len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 306 aa overlap). Probable ispE,4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.-), similar to others e.g. Q9K3R6|ISPE_STRCO Streptomyces coelicolor (299 aa), FASTA scores: opt: 925,E(): 2.7e-49, (54.5% identity in 297 overlap); etc. BELONGS TO THE ISPE FAMILY.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS11306421131562+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb1038|ispE
MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEGADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLLTSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARALRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVVSAPTEV
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