Gene Mb1108
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | cystathionine gamma-synthase metb (cgs) (o-succinylhomoserine [thiol]-lyase) |
| Comments | Mb1108, metB, len: 388 aa. Equivalent to Rv1079,len: 388 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 388 aa overlap). Probable metB,cystathionine gamma-synthase (EC 4.2.99.9) (see citation below). P46807|METB_MYCLE CYSTATHIONINE GAMMA-SYNTHASE from Mycobacterium leprae (EC 4.2.1.22) (388 aa), FASTA scores: opt: 2220, E(): 0, (87.3% identity in 387 aa overlap). Also similar to other Mycobacterium tuberculosis enzymes involved in methionine synthesis e.g. Rv0391 and Rv3340. Contains PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. BELONGS TO THE TRANS-SULFURATION ENZYMES FAMILY. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1205427 | 1206593 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb1108|metB
MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVGIEDIADLLGDLEQALG
Bibliography
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