Gene Mb1175 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemcr
Gene length1083 bp
IdentifierMb1175
Location 1271433 bp
Protein summary information
Molecular mass38684.9 Da
Isoelectric point4.7855
Protein length360 amino acids
Orthologs
M. tuberculosis H37RvRv1143
M. tuberculosis MTBC0mtbc0_001228
Cross-references
UniProtA0A1R3XXU6
InterProIPR003673, IPR023606
UniProtKB/TrEMBLQ7U0J6
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE ALPHA-METHYLACYL-COA RACEMASE MCR (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )
CommentsMb1175, mcr, len: 360 aa. Equivalent to Rv1143,len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 360 aa overlap). Probable mcr,alpha-methylacyl-CoA racemase (EC 5.1.99.4). Strong similarity to other alpha-methylacyl-CoA racemases and also some similarity to L-carnitine dehydratase (EC 4.2.1.89) e.g. U89905|g1552373 methylacyl-CoA racemase alpha from Norway rat (361 aa), FASTA scores: opt: 1035,E():0, (47.2% identity in 339 aa overlap). Equivalent to (but longer than) Z94723|MLCB33_13 Mycobacterium leprae (253 aa) (85.3% identity in 245 aa overlap). Also similar to Mycobacterium tuberculosis putative racemases Rv0855,Rv1866, Rv3272.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS12714331272515+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb1175|mcr
MAGPLSGLRVVELAGIGPGPHAAMILGDLGADVVRIDRPSSVDGISRDAMLRNRRIVTADLKSDQGLELALKLIAKADVLIEGYRPGVTERLGLGPEECAKVNDRLIYARMTGWGQTGPRSQQAGHDINYISLNGILHAIGRGDERPVPPLNLVGDFGGGSMFLLVGILAALWERQSSGKGQVVDAAMVDGSSVLIQMMWAMRATGMWTDTRGANMLDGGAPYYDTYECADGRYVAVGAIEPQFYAAMLAGLGLDAAELPPQNDRARWPELRALLTEAFASHDRDHWGAVFANSDACVTPVLAFGEVHNEPHIIERNTFYEANGGWQPMPAPRFSRTASSQPRPPAATIDIEAVLTDWDG
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