Gene Mb1225 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namefadD36
Gene length1422 bp
IdentifierMb1225
Location 1337044 bp
Protein summary information
Molecular mass49520.4 Da
Isoelectric point6.347
Protein length473 amino acids
Orthologs
M. tuberculosis H37RvRv1193
M. tuberculosis MTBC0mtbc0_001281
Cross-references
UniProtA0A1R3XXM7
InterProIPR000873, IPR020845, IPR025110
UniProtKB/TrEMBLQ7U0F2
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE FATTY-ACID-COA LIGASE FADD36 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)
CommentsMb1225, fadD36, len: 473 aa. Equivalent to Rv1193,len: 473 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 473 aa overlap). Probable fadD36,fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to Q50017|U15181 4-coumarate-CoA ligase from Mycobacterium leprae (476 aa), FASTA scores: opt: 2594, E(): 0, (81.3% identity in 476 aa overlap). Also highly similar to others e.g. CAB86109.1|AL163003 putative fatty acid synthase from Streptomyces coelicolor (485 aa); LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa), FASTA scores: opt: 605, E(): 8.4e-30, (33.0% identity in 364 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS13370441338465+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb1225|fadD36
MLLASLNPAVVSAADIADAVRIDGDVLSRSDLVGAATSVAERVAGAHRVAVLATPTASTVLAITGCLIAGVPVVPVPADVGVTERRHMLTDSGVQAWLGPLPDDPAGLPHIPVRTHARSWHRYPEPSPGAIAMVVYTSGTTGPPKGVQLSRRAIAADLDALAEAWQWTAEDVLVHGLPLYHVHGLVLGLLGSLRFGNRFVHTGKPTPAGYAQACYEAHGTLFFGVPTVWSRVAADQAAAGALKPARLLVSGSAALPVPVFDKLVQLTGHRPVERYGASESLITLSTRADGERRPGWVGLPLAGVQTRLVDDDGGEVPHDGETVGKLQVRGPTLFDGYLNQPDATAAAFDADSWYRTGDVAVVDGSGMHRIVGRESVDLIKSGGYRVGAGEIETVLLGHPDVAEAAVVGVPDDDLGQRIVAYVVGSANVDADGLINFVAQQLSVHKRPREVRIVDALPRNALGKVLKKQLLSEG
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