Gene Mb1297c in Mycobacterium bovis AF2122/97
Go to browser
virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepknH
Gene length1791 bp
IdentifierMb1297c
Location 1412196 bp
Protein summary information
Molecular mass63697.2 Da
Isoelectric point5.9903
Protein length596 amino acids
Orthologs
M. tuberculosis H37RvRv1266c
M. tuberculosis MTBC0mtbc0_001355
Cross-references
UniProtQ7U095
UniProtKB/TrEMBLX2BH99, Q7U095
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE H PKNH (PROTEIN KINASE H) (STPK H)
CommentsMb1297c, pknH, len: 596 aa. Similar to Rv1266c,len: 626 aa, from Mycobacterium tuberculosis strain H37Rv,(93.0% identity in 627 aa overlap). Probable pknH,transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citation below), similar to many e.g. PKN1_MYXXA|P33973 pkn1 (693 aa), FASTA scores: opt: 611,E(): 1.4e- 14, (29.7% identity in 492 aa overlap); etc. Contains PS00107 Protein kinases ATP-binding region signature; PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, the pknH gene contains several substitutions, transitions and transversions compared to Mycobacterium tuberculosis strain H37Rv. The most significant difference results from a 127 bp to 24 bp substitution that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (596 aa versus 626 aa).
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS14121961413986-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb1297c|pknH
MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTAEFSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTDLDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRDDFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYALACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGIPKAFDAVVARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPGTAAVTAQPPTMPTVTPPPIQAAPTGQPSWAPNSGPMPASGPTPTPQYYQGGGWGAPPSGGPSPWAQTPRKTNPWPLVAGAAAVVLVLVLGAIGIWIANRPKPVQPPQPVAEERLSALLLNSSEVNAVMGSSSMQPGKPITSMDSSPVTVSLPDCQGALYTSQDPVYAGTGYTAINGLISSEPGDNYEHWVNQAVVAFPTADKARAFVQTSADKWKNCAGKTVTVTNKAKTYRWTFADVKGSPPTITVIDTQEGAEGWECQRAMSVANNVVVDVNACGYQITNQAGQIAAKIVDKVNKE
Bibliography
No article yet recorded