Gene Mb1328 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namethrB
Gene length951 bp
IdentifierMb1328
Location 1450046 bp
Protein summary information
Molecular mass32346.4 Da
Isoelectric point4.744
Protein length316 amino acids
Orthologs
M. tuberculosis MTBC0mtbc0_001388
M. tuberculosis H37RvRv1296
Cross-references
UniProtP65225
UniProtKB/TrEMBLX2BHX2, P65225
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE HOMOSERINE KINASE THRB
CommentsMb1328, thrB, len: 316 aa. Equivalent to Rv1296,len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 316 aa overlap). Probable thrB,homoserine kinase (EC 2.7.1.39) (see citation below),highly similar to KHSE_MYCLE|P45836 from Mycobacterium leprae (314 aa), FASTA scores, opt: 1657, E(): 0, (82.0% identity in 311 aa overlap). Contains PS00639 Eukaryotic thiol (cysteine) proteases histidine active site, and PS00627 GHMP kinases putative ATP-binding domain.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS14500461450996+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb1328|thrB
MVTQALLPSGLVASAVVAASSANLGPGFDSVGLALSLYDEIIVETTDSGLTVTVDGEGGDQVPLGPEHLVVRAVQHGLQAAGVSAAGLAVRCRNAIPHSRGLGSSAAAVVGGLAAVNGLVVQTDSSPSSDAELIQLASEFEGHPDNAAAAVLGGAVVSWTDHSGDRPNYSAVSLRLHPDIRLFTAIPEQRSSTAETRVLLPAQVSHDDARFNVSRAALLVVALTERPDLLMAATEDLLHQPQRAAAMTASAEYLRLLRRHNVAAALSGAGPSLIALSTDSELPTDAVEFGAAKGFAVTELTVGEAVRWSPTVRVPG
Bibliography
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