Gene Mb1450 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameribA2
Gene length1278 bp
IdentifierMb1450
Location 1586704 bp
Protein summary information
Molecular mass46017.3 Da
Isoelectric point5.5655
Protein length425 amino acids
Orthologs
M. tuberculosis H37RvRv1415
M. tuberculosis MTBC0mtbc0_001515
Cross-references
UniProtP0A5V1
UniProtKB/TrEMBLX2BI18, P0A5V1
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBA2 : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase)
CommentsMb1450, ribA2, len: 425 aa. Equivalent to Rv1415,len: 425 aa, from Mycobacterium tuberculosis strain H37Rv,(100% identity in 425 aa overlap). Probable ribA2,Riboflavin biosynthesis protein (EC 3.5.4.25), similar to many e.g. GCH2_BACSU|P17620 from Bacillus subtilis (398 aa), FASTA scores: opt: 1388, E(): 0, (55.4% identity in 399 aa overlap). Also similar to second Mycobacterium tuberculosis gtp cyclohydrolase Rv1940|ribA1 (353 aa). IN THE N-TERMINAL SECTION; BELONGS TO THE DHBP SYNTHASE FAMILY. IN THE C-TERMINAL SECTION; BELONGS TO THE GTP CYCLOHYDROLASE II FAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS15867041587981+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb1450|ribA2
MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEKATPEMVAFMVRYTSGYLCVPLDGAICDRLGLLPMYAVNQDKHGTAYTVTVDARNGIGTGISASDRATTMRLLADPTSVADDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAHTDELRVFADEHGLALITIADLIEWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYEDVEHVALVRGEIAGPNADGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAALAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADTVDANLKLGLPADARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANAENIRYLMTKRDKLGHDLAGLDDFHESVHLPGEFGGAL
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