Gene Mb1742
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE 3-HYDROXYBUTYRYL-COA DEHYDROGENASE FADB3a [FIRST PART] (BETA-HYDROXYBUTYRYL-COA DEHYDROGENASE) (BHBD) |
| Comments | Mb1742, fadB3a, len: 187 aa. Equivalent to the 5' end of Rv1715, len: 304 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 187 aa overlap). Probable fadB3, 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157), highly similar to many e.g. NP_107236.1|NC_002678 3-hydroxybutyryl-CoA dehydrogenase from Mesorhizobium loti (309 aa); NP_250319.1|NC_002516 probable 3-hydroxyacyl-CoA dehydrogenase from Pseudomonas aeruginosa (509 aa); P45856|HBD_BACSU PROBABLE 3-HYDROXYBUTYRYL-COA DEHYDROGENASE from Bacillus subtilis (287 aa), FASTA scores: opt: 488, E(): 1.5e-24, (38.7% identity in 279 aa overlap); etc. COULD BELONG TO THE 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1715/fadB3 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) splits fadB3 into 2 parts, fadB3a and fadB3b. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1928000 | 1928563 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb1742|fadB3a
MLTSHGFSRAAVVGAGLMGRRIAGVLASAGLDVAITDTNAEILHAAAVEAARVAGAGRGSVAAAADLAAAIPDADLVIEAVVENLAVKQELFERLATLAPDAVLATNTSVLPIGAVTERVEDGSRVIGTHFWNPPDLIPVVEVVPSARTAPDTADRVVALLTQVGKLPVRVGRDVPGFIGNRLQHAL
Bibliography
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