Gene Mb1775 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepknF
Gene length1431 bp
IdentifierMb1775
Location 1957536 bp
Protein summary information
Molecular mass50698.2 Da
Isoelectric point5.8274
Protein length476 amino acids
Orthologs
M. tuberculosis H37RvRv1746
M. tuberculosis MTBC0mtbc0_001859
Cross-references
UniProtQ7TZN1
UniProtKB/TrEMBLX2BJ00, Q7TZN1
General annotation
TypeCDS
FunctionUnknown
ProductANCHORED-MEMBRANE SERINE/THREONINE-PROTEIN KINASE PKNF (PROTEIN KINASE F) (STPK F)
CommentsMb1775, pknF, len: 476 aa. Equivalent to Rv1746,len: 476 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 476 aa overlap). pknF, transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citations below), highly similar to KY28_MYCTU|Q10697 probable serine/threonine-protein kinase from Mycobacterium tuberculosis (589 aa), FASTA scores: opt: 870, E(): 0, (41.6% identity in 406 aa overlap). Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation. Start site chosen by homology, may extend further upstream.
Functional categoryRegulatory proteins
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS19575361958966+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb1775|pknF
MPLAEGSTFAGFTIVRQLGSGGMGEVYLARHPRLPRQDALKVLRADVSADGEYRARFNREADAAASLWHPHIVAVHDRGEFDGQLWIDMDFVDGTDTVSLLRDRYPNGMPGPEVTEIITAVAEALDYAHERRLLHRDVKPANILIANPDSPDRRIMLADFGIAGWVDDPSGLTATNMTVGTVSYAAPEQLMGNELDGRADQYALAATAFHLLTGSPPFQHANPAVVISQHLSASPPAIGDRVPELTPLDPVFAKALAKQPKDRYQRCVDFARALGHRLGGAGDPDDTRVSQPVAVAAPAKRSLLRTAVIVPAVLAMLLVMAVAVTVREFQRADDERAAQPARTRTTTSAGTTTSVAPASTTRPAPTTPTTTGAADTATASPTAAVVAIGALCFPLGSTGTTKTGATAYCSTLQGTNTTIWSLTEDTVASPTVTATADPTEAPLPIEQESPIRVCMQQTGQTRRECREEIRRSNGWP
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