Gene Mb1844 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameerg3
Gene length903 bp
IdentifierMb1844
Location 2046976 bp
Protein summary information
Molecular mass34882.4 Da
Isoelectric point9.9465
Protein length300 amino acids
Orthologues
M. tuberculosisRv1814
Cross-references
UniProtP68434
UniProtKB/TrEMBLX2BJ51, P68434
General annotation
TypeCDS
FunctionUnknown
ProductMEMBRANE-BOUND C-5 STEROL DESATURASE ERG3 (STEROL-C5-DESATURASE)
CommentsMb1844, erg3, len: 300 aa. Equivalent to Rv1814,len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 300 aa overlap). erg3, transmembrane C-5 sterol desaturase (EC 1.3.-.-) (see *), weak similarity to several e.g. ERG3_YEAST|P32353 c-5 sterol desaturase (365 aa), FASTA scores: opt: 154, E(): 0.0011,(22.9% identity in 288 aa overlap). BELONGS TO THE STEROL DESATURASE FAMILY. [* note work of Jackson, C.J., Lamb,D.C., Kelly, D.E., Kelly, S.L., Characterization of a sterol delta 5,6-desaturase homolog in Mycobacterium bovis (BCG). Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases].
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS20469762047878+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb1844|erg3
MRDPVLFAIPCFLLLLILEWTAARKLESIETAATGQPRPASGAYLTRDSVASISMGLVSIATTAGWKSLALLGYAAIYAYLAPWQLSAHRWYTWVIAIVGVDLLYYSYHRIAHRVRLIWATHQAHHSSEYFNFATALRQKWNNSGEILMWVPLPLMGLPPWMVFCSWSLNLIYQFWVHTERIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGGILIIWDRLFGSFQPELFRPHYGLTKRVDTFNIWKLQTREYVAIVRDWRSATRLRDRLGYVFGPPGWEPRTIDKSNAAASLVTSR
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