Gene Mb1863 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namegcvB
Gene length2826 bp
IdentifierMb1863
Location 2066229 bp
Protein summary information
Molecular mass99452.8 Da
Isoelectric point5.3538
Protein length941 amino acids
Orthologues
M. tuberculosisRv1832
Cross-references
UniProtQ7VET8
UniProtKB/TrEMBLX2BIL8, Q7VET8
General annotation
TypeCDS
FunctionUnknown
ProductProbable glycine dehydrogenase gcvB (Glycine decarboxylase) (Glycine cleavage system P-protein)
CommentsMb1863, gcvB, len: 941 aa. Equivalent to Rv1832,len: 941 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 941 aa overlap). Probable gcvB, glycine dehydrogenase [decarboxylating] (EC 1.4.4.2), highly similar to GCSP_ECOLI|P33195 glycine dehydrogenase (decarboxylating) from Escherichia coli (957 aa), FASTA scores: opt: 2194, E(): 0, (55.4% identity in 961 aa overlap). THE GLYCINE CLEAVAGE SYSTEM IS COMPOSED OF FOUR PROTEINS: P, T, L, AND H.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS20662292069054+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb1863|gcvB
MSDHSTFADRHIGLDSQAVATMLAVIGVDSLDDLAVKAVPAGILDTLTDTGAAPGLDSLPPAASEAEALAELRALADANTVAVSMIGQGYYDTHTPPVLLRNIIENPAWYTAYTPYQPEISQGRLEALLNFQTLVTDLTGLEIANASMLDEGTAAAEAMTLMHRAARGPVKRVVVDADVFTQTAAVLATRAKPLGIEIVTADLRAGLPDGEFFGAIAQLPGASGRITDWSALVQQAHDRGALVAVGADLLALTLIAPPGEIGADVAFGTTQRFGVPMGFGGPHAGYLAVHAKHARQLPGRLVGVSVDSDGTPAYRLALQTREQHIRRDKATSNICTAQVLLAVLAAMYASYHGAGGLTAIARRVHAHAEAIAGALGDALVHDKYFDTVLARVPGRADEVLARAKANGINLWRVDADHVSVACDEATTDTHVAVVLDAFGVAAAAPAHADIATRTSEFLTHPAFTQYRTETSMMRYLRALADKDIALDRSMIPLGSCTMKLNAAAEMESITWPEFGRQHPFAPASDTAGLRQLVADLQSWLVLITGYDAVSLQPNAGSQGEYAGLLAIHEYHASRGEPHRDICLIPSSAHGTNAASAALAGMRVVVVDCHDNGDVDLDDLRAKVGEHAERLSALMITYPSTHGVYEHDIAEICAAVHDAGGQVYVDGANLNALVGLARPGKFGGDVSHLNLHKTFCIPHGGGGPGVGPVAVRAHLAPFLPGHPFAPELPKGYPVSSAPYGSASILPITWAYIRMMGAEGLRAASLTAITSANYIARRLDEYYPVLYTGENGMVAHECILDLRGITKLTGITVDDVAKRLADYGFHAPTMSFPVAGTLMVEPTESESLAEVDAFCEAMIGIRAEIDKVGAGEWPVDDNPLRGAPHTAQCLLASDWDHPYTREQAAYPLGTAFRPKVWPAVRRIDGAYGDRNLVCSCPPVEAFA
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