Gene Mb1875c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE 6-PHOSPHOGLUCONATE DEHYDROGENASE GND1 |
| Comments | Mb1875c, gnd1, len: 705 aa. Similar to 5' end of Rv1844c, len: 485 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 404 aa overlap). Probable gnd1, 6-phosphogluconate dehydrogenase (EC 1.1.1.44). Similar to others e.g. 6PGD_ECOLI|P00350 from Escherichia coli (468 aa), FASTA scores: opt: 1661, E(): 0, (53.6% identity in 466 aa overlap); etc. Also similar to Rv1122|MTCY22G8.11|gnd2 PROBABLE 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING from Mycobacterium tuberculosis (340 aa), FASTA score: (33.0% identity in 351 aa overlap). Note that Rv1844c is most similar to gnd's from Gram negative organisms, while Rv1122|MTCY22G8.11|gnd2 is most similar to gnd's from Gram positive organisms. BELONGS TO THE 6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (c-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (705 aa versus 485 aa). |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2083281 | 2085338 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb1875c|gnd1
MGSNIARNFARHGYTVAVHNRSVAKTDALLKEHSSDGKFVRSETIPEFLAALEKPRRVLIMVKAGEATDAVINELADAMEPGDIIIDGGNALYTDTMRREKAMRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYQSLGPLLEEISAHVDGVPCCTHIGPDGSGHFVKMVHNGIEYSDMQLIGEAYQLMRDGLGLTAPAIADVFTEWNNGDLDSYLVEITAEVLRQTDAKTGKPLVDVIVDRAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALSGSVGQRSAASGLASGKLGEQPADPATFTEDVRQALYASKIVAYAQGFNQIQAGSAEFGWDITPGDLATIWRGGCIIRAKFLNHIKEAFDASPNLASLIVAPYFRAPSNRRSTVGGVWCRRRPNWVSRPRDSRRPCRITTRCAPRGCPLHSPRPSATSSAHTPTAGSTNQASSTHYGVQTAPKYRCSGLELKGGKGVSDEISRRAPTRVRPDIQRRVHRSEPIRGRVALRRRFVHRRRLGHHHSGSGRQYDRGSRAADGRDGRPPRWHRNPAAGSADPGGKADGGVRQKPGPGARHPSDAGTRRFGVRRHGAHPQARTWRRGGHPRGSPDRIGARIVLPGRGSLHPGARYRRDGLCDRSSGNRATQDLRPAGARPGRRCGADRRRRHVGGSAKPHRGYPRRYLHPGHR
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