Gene Mb1953c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namePPE35a
Gene length1878 bp
IdentifierMb1953c
Location 2160370 bp
Protein summary information
Molecular mass61971.6 Da
Isoelectric point5.8426
Protein length625 amino acids
Cross-references
UniProtA0A1R3XZR2
InterProIPR000030, IPR002989
UniProtKB/TrEMBLQ7TZA6
General annotation
TypeCDS
FunctionUnknown
ProductPPE FAMILY PROTEIN
CommentsMb1953c, PPE35a, len: 625 aa. Equivalent to 5'end of Rv1918c, len: 987 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 599 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins. Similar to MTCY28.16|Z95890 M. tuberculosis cosmid (1053 aa), FASTA scores: opt: 3404,E(): 0, (65.6% identity in 1058 aa overlap). Also similar to MTV004.05, MTY13E10.17, MTV014.03, MTCY3C7.23,MTCY6G11.05, MTCY48.17, MTV004.03, MTCY31.07, MTCY4C12.36,MTCY180.01, etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE35 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits PPE35 into 2 parts,PPE35a and PPE35b.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS21603702162247-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb1953c|PPE35a
MHYSVLPPEINSALIFAGAGSGPMLAAASAWDGLATELASAAVSFGSVTAGLVGGSWQGRSSVAMAAAAAPYAGWLAAAATQAEQAATQAQVMVAEFEAVRLAMVQPALVAANRSGLISLVISNLFGQNAPAIAAAEAAYEEMWALDVSAMAAYHSGASAVAVALPAFALPLRLPAGLAAGPAAVVTALTTAVGMPTFAGRAIAASLGLANVGGGNLGNANNGLGNIGNANLGNNNLGSGNFGSFNIGSANLGGNNIGIGNAGANNFGLANLGNLNTGFANAGIGNFGIANTGNNNIGNGLTGNNQIGIGGLNSGNGNVGLFNAGSANIGFFNSGNGNFGIGNSGNFSTGLFNPGHGNTGFLNAGSFNTGMFDVGNANTGSFNVGHYNFGAFNPGPSNTGTFNTGGANTGWFNTGSINTGAFNIGDMNNGLFNTGDMNNGVFYRGVGQGSLQFAITSPDLTLPSLEIPGISVPAFSLPAITLPSLTIPAVTTPANVTVGAFDLPGLTVPSLTIPAAMTPANITVGAFDLPGLTVPSLTIPATTTPANITVGAFNLPQLSIPSVTVPPITIPAGTALGAFNLPTLSIPSVTVPPITIPAGNHCRRIYATHDTHPVNKYTPNKYRRL
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