Gene Mb2025 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namefabG3
Gene length783 bp
IdentifierMb2025
Location 2226576 bp
Protein summary information
Molecular mass27029.7 Da
Isoelectric point4.7933
Protein length260 amino acids
Orthologs
M. tuberculosis H37RvRv2002
M. tuberculosis MTBC0mtbc0_002129
Cross-references
UniProtP69166
UniProtKB/TrEMBLX2BJ87, P69166
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE 20-BETA-HYDROXYSTEROID DEHYDROGENASE FABG3 (Cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase)
CommentsMb2025, fabG3, len: 260 aa. Equivalent to Rv2002,len: 260 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 260 aa overlap). Possible fabG3,20-beta-hydroxysteroid dehydrogenase (EC 1.1.1.53),similar to e.g. 2BHD_STREX|P19992 20-beta-hydroxysteroid dehydrogenase (255 aa), FASTA scores: opt: 718, E(): 2e-38, (49.8% identity in 243 aa overlap), and many mycobacterial proteins. Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS22265762227358+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2025|fabG3
MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAVAAELADAARYVHLDVTQPAQWTAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEAGRGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIRVNSIHPGLVKTPMTDWVPEDIFQTALGRAAEPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPEWVT
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