Gene Mb2077c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Polyprenol-monophosphomannose synthase Ppm1 |
| Comments | Mb2077c, ppm1, len: 874 aa. Equivalent to Rv2051c,len: 874 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 874 aa overlap). ppm1,Polyprenol-monophosphomannose synthase. Transfers mannose from GDP-Mannose to all endogenous polyprenol-phosphates in Mycobacterium tuberculosis, proven experimentally (A. Baulard, Institut Pasteur de Lille: see citation below). Very similar to polyprenol-phosphate-mannose synthases from Mycobacterium smegmatis (594 aa). Two-domain protein similar to products of two adjacent ORFs in Mycobacterium leprae MLCB2052.01 (644 aa), probable membrane protein and MLCB2052.02 (277 aa). First domain (aa 1 - 590) corresponds to membrane protein with similarity to P23930|LNT_ECOLI apolipoprotein n-acyltransferase (512 aa) while second domain (aa 591 -874) is similar to Schizosaccharomyces pombe dolichol monophosphate mannose synthase (236 aa) and to Mycobacterium tuberculosis Rv0539. FASTA scores: Z 98604|MLCB2052_1 (644 aa) opt: 2725 E(): 0 ; 67.7% identity in 601 aa overlap; and Z98604|MLCB2052_2 (277 aa) opt: 1449 E(): 0; 78.9% identity in 275 aa overlap; and gp|AF0078|AF007873_1 Schizosaccharomyces pombe dolichocholmonophosphate mannose synthase (236 aa) opt: 456 E(): 7.8e-19; 34.5% identity in 223 aa overlap and sp|P23930|LNT_ECOLI APOLIPOPROTEIN N-ACYLTRANSFERASE (512 aa) opt: 330 E(): 1.9e-11; 26.9% identity in 539 aa overlap; and polyprenol-phosphate-mannose synthases from Mycobacterium smegmatis (594 aa). CAC15462.1|AJ294477 putative polyprenol-phosphate-mannose synthase 2 (Ppm2): (55% identity in 533 aa overlap). |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2292044 | 2294668 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2077c|ppm1
MKLGAWVAAQLPTTRTAVRTRLTRLVVSIVAGLLLYASFPPRNCWWAAVVALALLAWVLTHRATTPVGGLGYGLLFGLVFYVSLLPWIGELVGPGPWLALATTCALFPGIFGLFAVVVRLLPGWPIWFAVGWAAQEWLKSILPFGGFPWGSVAFGQAEGPLLPLVQLGGVALLSTGVALVGCGLTAIALEIEKWWRTGGQGDAPPAVVLPAACICLVLFAAIVVWPQVRHAGSGSGGEPTVTVAVVQGNVPRLGLDFNAQRRAVLDNHVEETLRLAADVHAGLAQQPQFVIWPENSSDIDPFVNPDAGQRISAAAEAIGAPILIGTLMDVPGRPRENPEWTNTAIVWNPGTGPADRHDKAIVQPFGEYLPMPWLFRHLSGYADRAGHFVPGNGTGVVRIAGVPVGVATCWEVIFDRAPRKSILGGAQLLTVPSNNATFNKTMSEQQLAFAKVRAVEHDRYVVVAGTTGISAVIAPDGGELIRTDFFQPAYLDSQVRLKTRLTPATRWGPILQWILVGAAAAVVLVAMRQNGWFPRPRRSEPKGENDDSDAPPGRSEASGPPALSESDDELIQPEQGGRHSSGFGRHRATSRSYMTTGQPAPPAPGNRPSQRVLVIIPTFNERENLPVIHRRLTQACPAVHVLVVDDSSPDGTGQLADELAQADPGRTHVMHRTAKNGLGAAYLAGFAWGLSREYSVLVEMDADGSHAPEQLQRLLDAVDAGADLAIGSRYVAGGTVRNWPWRRLVLSKTANTYSRLALGIGIHDITAGYRAYRREALEAIDLDGVDSKGYCFQIDLTWRTVSNGFVVTEVPITFTERELGVSKMSGSNIREALVKVARWGIEGRLSRSDHARARPDIARPGAGGSRVSRADVTE
Bibliography
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