Gene Mb2115 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepknJ
Gene length1770 bp
IdentifierMb2115
Location 2326311 bp
Protein summary information
Molecular mass61595.4 Da
Isoelectric point7.8084
Protein length589 amino acids
Orthologs
M. tuberculosis H37RvRv2088
M. tuberculosis MTBC0mtbc0_002222
Cross-references
UniProtP65733
UniProtKB/TrEMBLX2BK37, P65733
General annotation
TypeCDS
FunctionUnknown
Producttransmembrane serine/threonine-protein kinase j pknj (protein kinase j) (stpk j)
CommentsMb2115, pknJ, len: 589 aa. Equivalent to Rv2088,len: 589 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 589 aa overlap). Probable pknJ,transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citation below), similar to other serine/threonine-protein kinases e.g. PKWA_THECU|P49695 putative serine/threonine-protein kinase (742 aa), FASTA scores: opt: 457, E(): 2.7e-15, (26.0% identity in 578 aa overlap); etc. Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation.
Functional categoryRegulatory proteins
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS23263112328080+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2115|pknJ
MAHELSAGSVFAGYRIERMLGAGGMGTVYLARNPDLPRSEALKVLAAELSRDLDFRARFVREADVAAGLDHPNIVAVHQRGQFEGRLWIAMQFVDGGNAEDALRAATMTTARAVYVIGEVAKALDYAHQQGVIHRDIKPANFLLSRAAGGDERVLLSDFGIARALGDTGLTSTGSVLATLAYAAPEVLAGQGFDGRADLYSLGCALFRLLTGEAPFAAGAGAAVAVVAGHLHQPPPTVSDRVPGLSAAMDAVIATAMAKDPMRRFTSAGEFAHAAAAALYGGATDGWVPPSPAPHVISQGAVPGSPWWQHPVGSVTALATPPGHGWPPGLPPLPRRPRRYRRGVAAVAAVMVVAAAAVTAVTMTSHQPRTATPPSAAALSPTSSSTTPPQPPIVTRSRLPGLLPPLDDVKNFVGIQNLVAHEPMLQPQTPNGSINPAECWPAVGGGVPSAYDLGTVIGFYGLTIDEPPTGTAPNQVGQLIVAFRDAATAQRHLADLASIWRRCGGRTVTLFRSEWRRPVELSTSVPEVVDGITTMVLTAQGPVLRVREDHAIAAKNNVLVDVDIMTPDTSRGQQAVIGITNYILAKIPG
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