Gene Mb2146c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehisE
Gene length282 bp
IdentifierMb2146c
Location 2361088 bp
Protein summary information
Molecular mass10274.6 Da
Isoelectric point4.3758
Protein length93 amino acids
Orthologs
M. tuberculosis H37RvRv2122c
M. tuberculosis MTBC0mtbc0_002254
Cross-references
UniProtP0A5B2
UniProtKB/TrEMBLX2BJR8, P0A5B2
General annotation
TypeCDS
FunctionUnknown
Productphosphoribosyl-amp pyrophosphatase hise
CommentsMb2146c, hisE, len: 93 aa. Equivalent to Rv2122c,len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 93 aa overlap). Probable hisE (alternate gene name: irg1), phosphoribosyl-AMP cyclohydrolase (EC 3.6.1.31) (see citation below), similar to N-terminus of e.g. HIS2_SYNY3 P74755 phosphoribosyl-AMP cyclohydrolase (230 aa), FASTA scores; opt: 150, E(): 4e-08, (37.9% identity in 87 aa overlap); etc. Note that previously misnamed hisI.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS23610882361369-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2146c|hisE
MQQSLAVKTFEDLFAELGDRARTRPADSTTVAALDGGVHALGKKLLEEAGEVWLAAEHESNDALAEEISQLLYWTQVLMISRGLSLDDVYRKL
Bibliography
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