Gene Mb2275
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | POSSIBLE FLAVOPROTEIN |
| Comments | Mb2275, -, len: 529 aa. Similar to 5' end of Rv2250A and 3' end of Rv2251, len: 139 aa and 475 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 108 aa overlap and 98.2% identity in 433 aa overlap). Rv2250A: Conserved hypothetical protein, possibly flavoprotein. Similar to N-terminus of SCF91.28c|AL132973_28 possible flavoprotein from Streptomyces coelicolor (530 aa), FASTA scores: opt: 240,E(): 1.1e-07, (39.25% identity in 107 aa overlap). Possible frameshift between nt 2525723 to 2525727. The sequences of CDC 1551 and Mycobacterium bovis are missing a single G base. Rv2251: Possible flavoprotein, probably continuation of Rv2250A, similar to MTCY164.18 from Mycobacterium tuberculosis and to several ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASES (e.g. O00116). Also some similarity to D-lactate dehydrogenases. FASTA scores: sptr|O05784|O05784 HYPOTHETICAL 56.5 KD PROTEIN. (527 aa) opt: 1019 E(): 0; (38.6% identity in 487 aa overlap) and sp|O00116|ADAS_HUMAN ALKYLDIHYDROXYACETON EPHOSPHATE SYNTHASE PRECURSOR (EC 2.5.1.26) (658 aa) opt: 558 E(): 6.2e-27; (31.3% identity in 447 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis H37Rv, Rv2250A and Rv2251 exist as 2 genes with an overlap region between them. In Mycobacterium bovis, a single base deletion (g-*) leads to a single product. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2504465 | 2506054 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2275|Mb2275
MKWDAWGDPAAAKPLSDGVRSLLKQVVGLADSEQPELDPAQVQLRPSALSGADHDALARIVGTEYFRTADRDRLLHAGGKSTPDLLRRKDTGVQDAPDAVLLPGGPNGEDAVADILHYCSDHGIAVVPFGGGTSVVGGLDPVRNDFRAVISLDMRRFDRLHRIDEVSGEAELEAGVTGPEAERLLGEHGFSLGHFPQSFEFATIGGFAATRSSGQDSAGYGRFNDMILGLRMITPVGVLDLGRVPASAAGPDLRQLAIGSEGVFGVITRVRLRVHRIPESTRYEAWSFPDFATGVAALRTITQTGTGPTVVRLSDEAETGVNLATTEAIGETQITGGCLGITVFEGTQEHTESRHAETRALLAARGGTSLGEGPARAWERGRFAAPYLRDSLLAAGALCETLETATVWSNTPVLKAAVTEALTTSLAASGTPALVMCHVSHVYPTGASLYFTVVAGQRGDPIEQWLAAKKAASDAIMATGGTITHHHAVGSDHRPWMRAEVGDLGVTLLRTIKATLDPAGILNPGKLIP
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