Gene Mb2283 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemscr
Gene length1086 bp
IdentifierMb2283
Location 2511201 bp
Protein summary information
Molecular mass37888.2 Da
Isoelectric point4.5377
Protein length361 amino acids
Orthologs
M. tuberculosis MTBC0mtbc0_002402
M. tuberculosis H37RvRv2259
Cross-references
UniProtA0A1R3Y2U2
InterProIPR002085, IPR002328, IPR011032, IPR013149, IPR013154, IPR016040, IPR017816
UniProtKB/TrEMBLQ7VEM6
General annotation
TypeCDS
FunctionUnknown
Products-nitrosomycothiol reductase mscr
CommentsMb2283, adhE2, len: 361 aa. Equivalent to Rv2259,len: 361 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 361 aa overlap). Probable adhE2,zinc-containing alcohol dehydrogenase, similar to several,especially mycothiol-dependent formaldehyde dehydrogenase from Amycolatopsis methanolica P80094 (360 aa). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. FASTA scores: >sp|P80094|FADH_AMYME NAD/MYCOTHIOL-DEPENDENT FORMALDEHYDE DEHYDROGENASE (MD-FALDH) Length = 360, Expect = e-156, Identities = 268/358 (74%). Also similar to Rv0162c, (MTCI28.02c, 35.0% identity in 371 aa overlap).
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS25112012512286+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2283|mscr
MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYREGGINDEYPFLLGHEAAGIIEAVGPGVTAVEPGDFVILNWRAVCGQCRACKRGRPRYCFDTFNAEQKMTLTDGTELTAALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGVTRDDTVAVIGCGGVGDAAIAGAALVGAKRIIAVDTDDTKLDWARTFGATHTVNAREVDVVQAIGGLTDGFGADVVIDAVGRPETYQQAFYARDLAGTVVLVGVPTPDMRLDMPLVDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQGRLPLQRFVSERIGLEDVEEAFHKMHGGKVLRSVVML
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