Gene Mb2347c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namerocE
Gene length1431 bp
IdentifierMb2347c
Location 2570318 bp
Protein summary information
Molecular mass49946.8 Da
Isoelectric point7.2317
Protein length476 amino acids
Orthologs
M. tuberculosis H37RvRv2320c
M. tuberculosis MTBC0mtbc0_002468
Cross-references
UniProtA0A1R3Y0V6
InterProIPR002293
UniProtKB/TrEMBLQ7TYU0
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE PROTEIN ROCE
CommentsMb2347c, rocE, len: 476 aa. Equivalent to Rv2320c,len: 476 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 476 aa overlap). Probable rocE,cationic amino acid (especially arginine and ornithine) transporter (permease), highly similar to other amino acid transporters e.g. Q9L100|SCL6.16C PUTATIVE AMINO ACID TRANSPORTER from Streptomyces coelicolor (496 aa), FASTA scores: opt: 1485, E(): 9.4e-82, (48.4% identity in 477 aa overlap); O06479|YFNA PUTATIVE AMINO ACID TRANSPORTER from Bacillus subtilis (462 aa), FASTA scores: opt: 1271, E(): 6.1e-69, (41.9% identity in 463 aa overlap); Q9PG94|XF0408 AMINO ACID TRANSPORTER from Xylella fastidiosa (509 aa),FASTA scores: opt: 1128, E(): 2.5e-60, (39.5% identity in 481 aa overlap); etc. Also some similarity with Z99108.1|BSUB0005 from Bacillus subtilis (461 aa), FASTA scores: opt: 1271, E(): 0, (41.9% identity in 463 aa overlap); and G403170 ETHANOLAMINE PERMEASE (488 aa),FASTA scores: opt: 468, E(): 1e-23, (28.1% identity in 462 aa overlap). SEEMS TO BELONG TO THE APC FAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS25703182571748-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2347c|rocE
MPTTSMSLRELMLRRRPVSGAPVASGASGNLKRSFGTFQLTMFGVGATIGTGIFFVLAQAVPEAGPGVIVSFIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLLEYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHPGWVNLPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSADHLKDFVPFGVAGIGSAAGTIFFSYIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALGTQPWQDFAEQETAGLAIILDNVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMGRDGLLPARFAKVNPRTMTPVHNTVIVAIFASTLAAFIPLDSLADMVSIGTLTAFSVVAVGVIVLRVREPDLPRGFKVPGYPVTPVLSVLACGYILASLHWYTWLAFSGWVAVAVIFYLMWGRHHSALNEEVP
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