Gene Mb2375c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameesxO
Gene length183 bp
IdentifierMb2375c
Location 2603485 bp
Protein summary information
Molecular mass6261.89 Da
Isoelectric point4.5385
Protein length60 amino acids
Orthologs
M. tuberculosis H37RvRv2346c
Cross-references
UniProtA0A1R3Y1C7
InterProIPR010310
UniProtKB/TrEMBLQ7TYS0
General annotation
TypeCDS
FunctionUnknown
Productputative esat-6 like protein esxo (esat-6 like protein 6)
CommentsMb2375c, esxO, len: 60 aa. Equivalent to 3' end of Rv2346c, len: 94 aa, from Mycobacterium tuberculosis strain H37Rv, (98.3% identity in 60 aa overlap). esxO,putative ESAT-6 like protein 6, conserved hypotheticalprotein, member of proteins family from Mycobacterium tuberculosis, with O53942|Rv1793|MTV049.15,O05300|Rv1198|MTCI364.10, MTCY15C10.33,P96364|MTCY07H7B.03|Rv1037c|MTCY10G2.12, MTCI364.10, etc. BELONGS TO THE ESAT6 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large 8963 bp deletion (RD5) leads to the loss of the NH2 part of Mb2375c, and the 9 following CDSs up to Rv2356 including the 3 phospolipases C enzymes plcC, plcB and plcA, compared to the homolog in Mycobacterium tuberculosis H37Rv.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS26034852603667-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2375c|esxO
MLAAGDFWGGAGSVACQEFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA
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