Gene Mb2451c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameproA
Gene length1248 bp
IdentifierMb2451c
Location 2692393 bp
Protein summary information
Molecular mass43744.7 Da
Isoelectric point5.9312
Protein length415 amino acids
Cross-references
UniProtKB/TrEMBLX2BKG4, P65789
SWISS-MODELP65789
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDEHYDE DEHYDROGENASE)
CommentsMb2451c, proA, len: 415 aa. Equivalent to Rv2427c,len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 415 aa overlap). Probable proA,gamma-glutamyl phosphate reductase protein (EC 1.2.1.41),equivalent to Q9CBZ7|ML1458|PROA [GAMMA]-GLUTAMYL PHOSPHATE REDUCTASE from Mycobacterium leprae (409 aa),FASTA scores: opt: 2120, E(): 7.4e-118, (81.9% identity in 409 aa overlap). Also highly similar or similar to other GAMMA-GLUTAMYL PHOSPHATE REDUCTASES PROTEINS (GPR) e.g. Q9RDK1|PROA from Streptomyces coelicolor (428 aa), FASTA scores: opt: 1073, E(): 4.6e-56, (60.4% identity in 429 aa overlap); P45638|PROA_CORGL from Corynebacterium glutamicum (432 aa), FASTA scores: opt: 993, E(): 2.4e-51,(58.5% identity in 417 aa overlap); P96489|PROA_STRTR GAMMA-GLUTAMYL PHOSPHATE REDUCTASE from Streptococcus thermophilus (416 aa), FASTA scores: opt: 863, E(): 1.1e-43, (49.15% identity in 413 aa overlap); etc. BELONGS TO THE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE FAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS26923932693640-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2451c|proA
MTVPAPSQLDLRQEVHDAARRARVAARRLASLPTTVKDRALHAAADELLAHRDQILAANAEDLNAAREADTPAAMLDRLSLNPQRVDGIAAGLRQVAGLRDPVGEVLRGYTLPNGLQLRQQRVPLGVVGMIYEGRPNVTVDAFGLTLKSGNAALLRGSSSAAKSNEALVAVLRTALVGLELPADAVQLLSAADRATVTHLIQARGLVDVVIPRGGAGLIEAVVRDAQVPTIETGVGNCHVYVHQAADLDVAERILLNSKTRRPSVCNAAETLLVDAAIAETALPRLLAALQHAGVTVHLDPDEADLRREYLSLDIAVAVVDGVDAAIAHINEYGTGHTEAIVTTNLDAAQRFTEQIDAAAVMVNASTAFTDGEQFGFGAEIGISTQKLHARGPMGLPELTSTKWIAWGAGHTRPA
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