Gene Mb2537 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameMb2537
Gene length807 bp
IdentifierMb2537
Location 2791475 bp
Protein summary information
Molecular mass28013.2 Da
Isoelectric point9.0131
Protein length268 amino acids
Orthologs
M. tuberculosis H37RvRv2509
M. tuberculosis MTBC0mtbc0_002671
Cross-references
InterProIPR002198, IPR002347, IPR016040, IPR020904
UniProtKB/TrEMBLQ7TYF1
SWISS-MODELA0A1R3Y1F1
General annotation
TypeCDS
FunctionUnknown
Productprobable short-chain type dehydrogenase/reductase
CommentsMb2537, -, len: 268 aa. Equivalent to Rv2509, len: 268 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 268 aa overlap). Probable ala-rich oxidoreductase, short-chain dehydrogenase/reductase (EC 1.-.-.-), equivalent to O07709|MLCL383.36c|ML0429 DEHYDROGENASE (PUTATIVE OXIDOREDUCTASE) from Mycobacterium leprae (268 aa), FASTA scores: opt: 1509, E(): 2.6e-84,(88.75% identity in 267 aa overlap). Also highly similar to others e.g. O86553|SC1F2.16c PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (276 aa), FASTA scores: opt: 492, E(): 9.5e-23, (38.15% identity in 262 aa overlap); Q9I5R3|PA0658 PROBABLE SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (266 aa), FASTA scores: opt: 472,E(): 1.5e-21, (37.8% identity in 246 aa overlap); AAK22120|CC0133 OXIDOREDUCTASE (SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY) from Caulobacter crescentus (266 aa), FASTA scores: opt: 428, E(): 6.9e-19,(35.8% identity in 243 aa overlap); etc. Also highly similar or similar to oxidoreductases from Mycobacterium tuberculosis e.g. Q10782|Rv1544|MTCY48.21 PUTATIVE KETOACYL REDUCTASE (EC 1.3.1.-) (267 aa), FASTA scores: opt: 656, E(): 1.1e-32, (43.05% identity in 267 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS27914752792281+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2537|Mb2537
MPIPAPSPDARAVVTGASQNIGAALATELAARGHHLIVTARREDVLTELAARLADKYRVTVDVRPADLADPQERSKLADELAARPISILCANAGTATFGPIASLDLAGEKTQVQLNAVAVHDLTLAVLPGMIERKAGGILISGSAAGNSPIPYNATYAATKAFVNTFSESLRGELRGSGVHVTVLAPGPVRTELPDASEASLVEKLVPDFLWISTEHTARVSLNALERNKMRVVPGLTSKAMSVASQYAPRAIVAPIVGAFYKRLGGS
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