Gene Mb2567c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namearoB
Gene length1089 bp
IdentifierMb2567c
Location 2828385 bp
Protein summary information
Molecular mass38119.1 Da
Isoelectric point5.1241
Protein length362 amino acids
Cross-references
UniProtKB/TrEMBLX2BL40, P0A4Z5
SWISS-MODELP0A4Z5
General annotation
TypeCDS
FunctionUnknown
Product3-DEHYDROQUINATE SYNTHASE AROB
CommentsMb2567c, aroB, len: 362 aa. Equivalent to Rv2538c,len: 362 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 362 aa overlap). aroB,3-dehydroquinate synthase (EC 4.2.3.4) (see citation below), equivalent to Q9CCS4|AROB_MYCLE|ML0518 3-DEHYDROQUINATE SYNTHASE from Mycobacterium leprae (361 aa), FASTA scores: opt: 2059, E(): 3.3e-117, (87.25% identity in 361 aa overlap). Also highly similar to many e.g. Q9KXQ6|AROB from Streptomyces coelicolor (363 aa),FASTA scores: opt: 1363, E(): 4e-75, (60.05% identity in 358 aa overlap); Q9X5D2|AROB_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (366 aa), FASTA scores: opt: 1154, E(): 1.7e-62, (50.95% identity in 359 aa overlap); P07639|AROB_ECOLI|B3389 from Escherichia coli strain K12 (362 aa), FASTA scores: opt: 771, E(): 2.4e-39,(40.6% identity in 345 aa overlap); etc. BELONGS TO THE DEHYDROQUINATE SYNTHASE FAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS28283852829473-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2567c|aroB
MTDIGAPVTVQVAVDPPYPVVIGTGLLDELEDLLADRHKVAVVHQPGLAETAEEIRKRLAGKGVDAHRIEIPDAEAGKDLPVVGFIWEVLGRIGIGRKDALVSLGGGAATDVAGFAAATWLRGVSIVHLPTTLLGMVDAAVGGKTGINTDAGKNLVGAFHQPLAVLVDLATLQTLPRDEMICGMAEVVKAGFIADPVILDLIEADPQAALDPAGDVLPELIRRAITVKAEVVAADEKESELREILNYGHTLGHAIERRERYRWRHGAAVSVGLVFAAELARLAGRLDDATAQRHRTILSSLGLPVSYDPDALPQLLEIMAGDKKTRAGVLRFVVLDGLAKPGRMVGPDPGLLVTAYAGVCAP
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