Gene Mb2612c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameMb2612c
Gene length675 bp
IdentifierMb2612c
Location 2873537 bp
Protein summary information
Molecular mass24197.6 Da
Isoelectric point6.6261
Protein length224 amino acids
Orthologs
M. tuberculosis H37RvRv2581c
M. tuberculosis MTBC0mtbc0_002748
Cross-references
UniProtKB/TrEMBLX2BLR5, P64262
SWISS-MODELP64262
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE GLYOXALASE II (HYDROXYACYLGLUTATHIONE HYDROLASE) (GLX II)
CommentsMb2612c, -, len: 224 aa. Equivalent to Rv2581c,len: 224 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 224 aa overlap). Possible glyoxalase II (EC 3.1.2.6), equivalent to Q49649|YP81_MYCLE|ML0493|MLCB1259.11|B1177_C3_247 HYPOTHETICAL 23.9 KDA PROTEIN from Mycobacterium leprae (218 aa), FASTA scores: opt: 1264, E(): 7.8e-73, (82.0% identity in 222 aa overlap). Also highly similar to Q9KXP1|SC9C5.33c POSSIBLE HYDROLASE from Streptomyces coelicolor (235 aa), FASTA scores: opt: 654, E(): 2.9e-34,(46.8% identity in 220 aa overlap); and similar to Q9CI24|YFCI HYPOTHETICAL PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (210 aa), FASTA scores: opt: 360, E(): 9.9e-16, (35.0% identity in 217 aa overlap); AAK75726|SP1646 METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN from Streptococcus pneumoniae (209 aa), FASTA scores: opt: 320, E(): 3.3e-13, (35.85% identity in 198 aa overlap); AAK80229|CAC2272 PREDICTED ZN-DEPENDENT HYDROLASE OF METALLO-BETA-LACTAMASE SUPERFAMILY from Clostridium acetobutylicum (199 aa),FASTA scores: opt: 282, E(): 8e-11, (32.7% identity in 217 aa overlap); etc. Equivalent to AAK46971 from Mycobacterium tuberculosis strain CDC1551 (246 aa) but shorter 22 aa. BELONGS TO THE GLYOXALASE II FAMILY. COFACTOR: BINDS TWO ZINC IONS.
Functional categoryVirulence, detoxification, adaptation
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS28735372874211-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2612c|Mb2612c
MLITGFPAGLLACNCYVLAERPGTDAVIVDPGQGAMGTLRRILDKNRLTPAAVLLTHGHIDHIWSAQKVSDTFGCPTYVHPADRFMLTDPIYGLGPRIAQLVAGAFFREPKQVVELDRDGDKIDLGGISVNIDHTPGHTRGSVVFRVLQATNNDKDIVFTGDTLFERAIGRTDLAGGSGRDLLRSIVDKLLVLDDSTVVLPGHGNSTTIGAERRFNPFLEGLSR
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