Gene Mb2871c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameefpA
Gene length1593 bp
IdentifierMb2871c
Location 3109609 bp
Protein summary information
Molecular mass55634.6 Da
Isoelectric point9.9177
Protein length530 amino acids
Orthologs
M. tuberculosis H37RvRv2846c
M. tuberculosis MTBC0mtbc0_003025
Cross-references
InterProIPR011701, IPR016196, IPR020846
UniProtKB/TrEMBLQ7TXQ4
SWISS-MODELA0A1R3Y2D5
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE INTEGRAL MEMBRANE EFFLUX PROTEIN EFPA
CommentsMb2871c, efpA, len: 530 aa. Equivalent to Rv2846c,len: 530 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 530 aa overlap). Possible efpA,integral membrane efflux protein, member of major facilitator superfamily (MFS) possibly involved in transport of drug (see citations below), equivalent to Q9Z5J5|ML1562|MLCB596.08 PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Mycobacterium leprae (534 aa), FASTA scores: opt: 2881, E(): 4.1e-160, (86.55% identity in 535 aa overlap). Also highly similar to several membrane proteins e.g. O69986|SC4H2.31c TRANSMEMBRANE EFFLUX PROTEIN (515 aa), FASTA scores: opt: 1063, E(): 2.2e-54, (39.65% identity in 406 aa overlap); Q9FBQ5|SCD86A.02c PUTATIVE TRANSPORT INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (503 aa), FASTA scores: opt: 918, E(): 5.8e-46,(33.7% identity in 469 aa overlap); Q9KYU0|SCE22.23c PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (514 aa), FASTA scores: opt: 888, E(): 3.3e-44,(32.85% identity in 469 aa overlap); etc.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS31096093111201-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2871c|efpA
MTALNDTERAVRNWRAGRPHRPAPMRPPRSEETASERPSRYYPTWLPSRSFIAAVIAIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEATLVIARLSQGVGSAIASPTGLALVATTFPKGPARNAATAVFAAMTAIGSVMGLVVGGALTEVSWRWAFLVNVPIGLVMIYLARTALRETNKERMKLDATGAILATLACTAAVFAFSIGPEKGWMSGITIGSGLVALAAAVAFVIVERTAENPVVPFHLFRDRNRLVTFSAILLAGGVMFSLTVCIGLYVQDILGYSALRAGVGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLLFGAMLYGSFFMHRGVPYFPNLVMPIVVGGIGIGMAVVPLTLSAIAGVGFDQIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDVQLAALDHAYTYGLLWVAGAAIIVGGMALFIGYTPQQVAHAQEVKEAIDAGEL
Bibliography
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