Gene Mb2880
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | nadph-dependent mycothiol reductase mtr |
| Comments | Mb2880, mtr, len: 459 aa. Equivalent to Rv2855,len: 459 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 459 aa overlap). Probable mtr,mycothiol reductase (EC 1.-.-.-), proven enzymatically but previously described as glutathione reductase homolog (gene name: gorA) (see citation below). Similar to others e.g. Q9L7K8|MERA MERCURIC REDUCTASE from Streptomyces sp. CHR28 (474 aa), FASTA scores: opt: 719, E(): 9e-38, (35.2% identity in 460 aa overlap); P30341|MERA_STRLI MERCURIC REDUCTASE (EC 1.16.1.1) from Streptomyces lividans (474 aa), FASTA scores: opt: 712, E(): 2.5e-37, (34.95% identity in 455 aa overlap); Q98ED5|MLL4296 FERRIC LEGHEMOGLOBIN REDUCTASE-2 PRECURSOR, DIHYDROLIPOAMIDE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (468 aa), FASTA scores: opt: 670, E(): 1.1e-34, (30.8% identity in 471 aa overlap); etc. BELONGS TO THE PYRIDINE NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASES CLASS-I. COFACTOR: FAD. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3121721 | 3123100 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2880|mtr
METYDIAIIGTGSGNSILDERYASKRAAICEQGTFGGTCLNVGCIPTKMFVYAAEVAKTIRGASRYGIDAHIDRVRWDDVVSRVFGRIDPIALSGEDYRRCAPNIDVYRTHTRFGPVQADGRYLLRTDAGEEFTAEQVVIAAGSRPVIPPAILASGVDYHTSDTVMRIAELPEHIVIVGSGFIAAEFAHVFSALGVRVTLVIRGSCLLRHCDDTICERFTRIASTKWELRTHRNVVDGQQRGSGVALRLDDGCTINADLLLVATGRVSNADLLDAEQAGVDVEDGRVIVDEYQRTSARGVFALGDVSSPYLLKHVANHEARVVQHNLLCDWEDTQSMIVTDHRYVPAAVFTDPQIAAVGLTENQAVAKGLDISVKIQDYGDVAYGWAMEDTSGIVKLITERGSGRLLGAHIMGYQASSLIQPLIQAMSFGLTAAEMARGQYWIHPALPEVVENALLGLR
Bibliography
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