Gene Mb2881 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namenicT
Gene length1119 bp
IdentifierMb2881
Location 3123200 bp
Protein summary information
Molecular mass40534.4 Da
Isoelectric point8.2446
Protein length372 amino acids
Orthologs
M. tuberculosis H37RvRv2856
M. tuberculosis MTBC0mtbc0_003035
Cross-references
InterProIPR004688, IPR011541
UniProtKB/TrEMBLQ7TXP7
SWISS-MODELA0A1R3Y2E6
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE NICKEL-TRANSPORT INTEGRAL MEMBRANE PROTEIN NICT
CommentsMb2881, nicT, len: 372 aa. Equivalent to Rv2856,len: 372 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 372 aa overlap). Possible nicT,nickel-transport integral membrane protein, similar to transport proteins and hydrogenase cluster proteins e.g. BAB58860|SAV2698 HYPOTHETICAL 37.9 KDA PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (338 aa), FASTA scores: opt: 1082, E(): 7.1e-60, (48.05% identity in 335 aa overlap); Q97ZB2|HOXN HIGH-AFFINITY NICKEL-TRANSPORT PROTEIN from Sulfolobus solfataricus (373 aa), FASTA scores: opt: 922, E(): 6.6e-50, (42.2% identity in 372 aa overlap); P23516|HOXN_ALCEU HIGH-AFFINITY NICKEL TRANSPORT PROTEIN (INTEGRAL MEMBRANE PROTEIN) from Alcaligenes eutrophus (Ralstonia eutropha) (351 aa), FASTA scores: opt: 904, E(): 8.3e-49, (41.9% identity in 339 aa overlap); Q45247|HUPN_BRAJA HYDROGENASE NICKEL INCORPORATION PROTEIN from Bradyrhizobium japonicum (381 aa), FASTA scores: opt: 853, E(): 1.3e-45, (41.65% identity in 329 aa overlap); etc. SEEMS TO BELONG TO THE HOXN/HUPN/NIXA FAMILY OF NICKEL TRANSPORTERS (NiCoT FAMILY).
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS31232003124318+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2881|nicT
MASSQLDRQRSRSAKMNRALTAAEWWRLGLMFAVIVALHLVGWLTVTLLVEPARLSLGGKAFGIGVGLTAYTLGLRHAFDADHIAAIDNTTRKLMSDGHRPLAVGFFFSLGHSTVVFGLAVMLVTGLKAIVGPVENDSSTLHHYTGLIGTSISGAFLYLIGILNVIVLVGIVRVFAHLRRGDYDEAELEQQLDNRGLLIRFLGRFTKSLTKSWHMYPVGFLFGLGFDTATEIALLVLAGTSAAAGLPWYAILCLPVLFAAGMCLLDTIDGSFMNFAYGWAFSSPVRKIYYNITVTGLSVAVALLIGSVELLGLIANQLGWQGPFWDWLGGLDLNTVGFVVVAMFALTWAIALLVWHYGRVEERWTPAPDRTT
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