Gene Mb2895c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namedxr
Gene length1242 bp
IdentifierMb2895c
Location 3138286 bp
Protein summary information
Molecular mass42853.5 Da
Isoelectric point5.5447
Protein length413 amino acids
Orthologs
M. tuberculosis H37RvRv2870c
M. tuberculosis MTBC0mtbc0_003052
Cross-references
UniProtKB/TrEMBLX2BLS9, P64013
SWISS-MODELP64013
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERASE)
CommentsMb2895c, dxr, len: 413 aa. Equivalent to Rv2870c,len: 413 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 413 aa overlap). Probable dxr,1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.-), equivalent to Q9CBU3|DXR|ML1583 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE from Mycobacterium leprae (406 aa), FASTA scores: opt: 2145,E(): 1e-124, (84.05% identity in 395 aa overlap). Also highly similar to others e.g. Q9AJD7|DXR from Kitasatospora griseola (Streptomyces griseolosporeus) (386 aa), FASTA scores: opt: 1176, E(): 5.2e-65, (56.45% identity in 388 aa overlap); Q9KYS1|DXR_STRCO|SC5H4.18 from Streptomyces coelicolor (401 aa), FASTA scores: opt: 1079, E(): 5.1e-59, (52.25% identity in 396 aa overlap); P45568|DXR|B0173 from Escherichia coli strain K12 (398 aa), FASTA scores: opt: 120, E(): 0.032, (52.9% identity in 34 aa overlap); etc. Contains PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. BELONGS TO THE DXR FAMILY. N-terminus shortened since first submission.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS31382863139527-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2895c|dxr
MTNSTDGRADGRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSGMASVAIASTAKPGAAGRHASTLERS
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