Gene Mb2927c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE SIGNAL PEPTIDASE I LEPB (SPASE I) (LEADER PEPTIDASE I). |
| Comments | Mb2927c, lepB, len: 294 aa. Equivalent to Rv2903c,len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 294 aa overlap). Probable lepB, signal peptidase I (EC 3.4.21.89) (TYPE II MEMBRANE PROTEIN) (see first citation below), equivalent to O33021|LEP_MYCLE|ML1612|MLCB250.39 PROBABLE SIGNAL PEPTIDASE I from Mycobacterium leprae (289 aa), FASTA scores: opt: 1335, E(): 1.8e-77, (69.75% identity in 301 aa overlap). Also similar to many e.g. O86869|SIPX SIGNAL PEPTIDASE I from Streptomyces lividans (320 aa), FASTA scores: opt: 474, E(): 1e-22, (43.55% identity in 248 aa overlap); O69884|SIP1|SIPW PUTATIVE SIGNAL PEPTIDASE I from Streptomyces coelicolor and Streptomyces lividans (259 aa), FASTA scores: opt: 226, E(): 5e-07, (36.0% identity in 214 aa overlap); P42668|LEP_BACLI|SIP SIGNAL PEPTIDASE I from Bacillus licheniformis (186 aa), FASTA scores: opt: 218, E(): 1.3e-06, (34.5% identity in 194 aa overlap); etc. Contains PS00501 Signal peptidases I serine active site,and PS00761 Signal peptidases I signature 3. BELONGS TO PEPTIDASE FAMILY S26; ALSO KNOWN AS TYPE I LEADER PEPTIDASE FAMILY. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3169486 | 3170370 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2927c|lepB
MTETTDSPSERQPGPAEPELSSRDPDIAGQVFDAAPFDAAPDADSEGDSKAAKTDEPRPAKRSTLREFAVLAVIAVVLYYVMLTFVARPYLIPSESMEPTLHGCSTCVGDRIMVDKLSYRFGSPQPGDVIVFRGPPSWNVGYKSIRSHNVAVRWVQNALSFIGFVPPDENDLVKRVIAVGGQTVQCRSDTGLTVNGRPLKEPYLDPATMMADPSIYPCLGSEFGPVTVPPGRVWVMGDNRTHSADSRAHCPLLCTNDPLPGTVPVANVIGKARLIVWPPSRWGVVRSVNPQQGR
Bibliography
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