Gene Mb2940c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | probable signal recognition particle protein ffh (fifty-four homolog) (srp protein) |
| Comments | Mb2940c, ffh, len: 525 aa. Equivalent to Rv2916c,len: 525 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 525 aa overlap). Probable ffh, signal recognition particle protein (ala-, gly-, leu-rich protein), equivalent to O33013|SR54_MYCLE SIGNAL RECOGNITION PARTICLE from Mycobacterium leprae (521 aa),FASTA scores: opt: 2968, E(): 1.6e-145, (87.85% identity in 526 aa overlap). Also highly similar to others e.g. O69874|FFH from Streptomyces coelicolor (550 aa), FASTA scores: opt: 2025, E(): 6e-97, (63.8% identity in 519 aa overlap) (N-terminus longer 34 aa); P37105|SR54_BACSU from Bacillus subtilis (446 aa), FASTA scores: opt: 1451, E(): 1.9e-67, (51.5% identity in 435 aa overlap); BAB57399|FFH from Staphylococcus aureus subsp. aureus Mu50 (455 aa),FASTA scores: opt: 1418, E(): 9.4e-66, (48.65% identity in 448 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE SRP FAMILY OF GTP-BINDING PROTEINS. NOTE THAT SIGNAL RECOGNITION PARTICLE CONSISTS OF A SMALL CYTOPLASMIC RNA (SC-RNA) MOLECULE AND PROTEIN FFH. THE PROTEIN HAS A TWO DOMAIN STRUCTURE: THE G-DOMAIN BINDS GTP; THE M-DOMAIN BINDS THE RNA AND ALSO BINDS THE SIGNAL SEQUENCE. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3181224 | 3182801 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2940c|ffh
MFESLSDRLTAALQGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFIHRIKERARGAEVSSALNPAQQVVKIVNEELISILGGETRELAFAKTPPTVVMLAGLQGSGKTTLAGKLAARLRGQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFAPHPGASPESGPGDPVAVAAAGLAEARAKHFDVVIVDTAGRLGIDEELMAQAAAIRDAINPDEVLFVLDAMIGQDAVTTAAAFGEGVGFTGVALTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMASRILGMGDVLSLIEQAEQVFDAQQAEEAAAKIGAGELTLEDFLEQMLAVRKMGPIGNLLGMLPGAAQMKDALAEVDDKQLDRVQAIIRGMTPQERADPKIINASRRLRIANGSGVTVSEVNQLVERFFEARKMMSSMLGGMGIPGIGRKSATRKSKGAKGKSGKKSKKGTRGPTPPKVKSPFGVPGMPGLAGLPGGLPDLSQMPKGLDELPPGLADFDLSKLKFPGKK
Bibliography
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