Gene Mb2949c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE FPG (FAPY-DNA GLYCOSYLASE) |
| Comments | Mb2949c, fpg, len: 289 aa. Equivalent to Rv2924c,len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 289 aa overlap). Probable fpg (alternate gene name: mutM), formamidopyrimidine-DNA glycosylase (EC 3.2.2.23), equivalent to O69470|FPG_MYCLE FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE from Mycobacterium leprae (282 aa), FASTA scores: opt: 1563, E(): 1.3e-96,(80.6% identity in 289 aa overlap). Also highly similar to other formamidopyrimidine-DNA glycosylases e.g. Q9ZBQ6|FPG_STRCO from Streptomyces coelicolor (286 aa),FASTA scores: opt: 1047, E(): 2.9e-62, (57.55% identity in 292 aa overlap); P95744|FPG_SYNEN from Synechococcus elongatus naegeli (284 aa), FASTA scores: opt: 569, E(): 1.9e-30, (37.95% identity in 290 aa overlap); P05523|FPG_ECOLI|MUTM|FPG|B3635 from Escherichia coli strain K12 (269 aa), FASTA scores: opt: 424, E(): 8.2e-21,(33.9% identity in 289 aa overlap); etc. BELONGS TO THE FPG FAMILY. COFACTOR: BINDS 1 ZINC ION. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3195229 | 3196098 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2949c|fpg
MPELPEVEVVRRGLQAHVTGRTITEVRVHHPRAVRRHDAGPADLTARLRGARINGTDRRGKYLWLTLNTAGVHRPTDTALVVHLGMSGQMLLGAVPCAAHVRISALLDDGTVLSFADQRTFGGWLLADLVTVDGSVVPVPVAHLARDPLDPRFDCDAVVKVLRRKHSELKRQLLDQRVVSGIGNIYADEALWRAKVNGAHVAATLRCRRLGAVLHAAADVMREALAKGGTSFDSLYVNVNGESGYFERSLDAYGREGENCRRCGAVIRRERFMNRSSFYCPRCQPRPRK
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