Gene Mb3012c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE 3-ISOPROPYLMALATE DEHYDRATASE (LARGE SUBUNIT) LEUC (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) |
| Comments | Mb3012c, leuC, len: 473 aa. Equivalent to Rv2988c,len: 473 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 473 aa overlap). Probable leuC,3-isopropylmalate dehydratase, large subunit (EC 4.2.1.33), equivalent to O33123|LEU2_MYCLE 3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT from Mycobacterium leprae (476 aa), FASTA scores: opt: 2818,E(): 1.3e-171, (88.75% identity in 471 aa overlap). Also highly similar to many e.g. Q44427|LEU2_ACTTI from Actinoplanes teichomyceticus (485 aa), FASTA scores: opt: 1958, E(): 6.5e-117, (71.0% identity in 479 aa overlap); P55251|LEU2_RHIPU from Rhizomucor pusillus (755 aa), FASTA scores: opt: 1937, E(): 1.9e-115, (61.25% identity in 467 aa overlap) (C-terminus longer); P30127|LEU2_ECOLI|LEUC|B0072 from Escherichia coli strain K12 (465 aa), FASTA scores: opt: 1896, E(): 5.5e-113,(61.6% identity in 456 aa overlap); etc. Contains PS00450 Aconitase family signature. BELONGS TO THE ACONITASE/IPM ISOMERASE FAMILY. TBparse score is 0.895. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3301214 | 3302635 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3012c|leuC
MALQTGEPRTLAEKIWDDHIVVSGGGCAPDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPELTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPDGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPGQGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMREIAVDAVFVGSCTNGRIEDLRVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNPDQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN
Bibliography
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