Gene Mb3051c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | cysteine desulfurase iscs (nifs protein homolog) (nitrogenase metalloclusters biosynthesis protein nifs) |
| Comments | Mb3051c, iscS, len: 393 aa. Equivalent to Rv3025c,len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 393 aa overlap). Probable iscS (alternate gene name: nifS), cysteine desulfurase (NifS-like protein) (EC 4.4.1.-), equivalent to MLCB637.06|O33098 NIFS-LIKE PROTEIN from Mycobacterium leprae (396 aa), FASTA scores: opt: 2186, E(): 2.7e-122,(84.9% identity in 391 aa overlap). Also highly similar to many e.g. O86581|SC2A11.20 PUTATIVE PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASE from Streptomyces coelicolor (389 aa), FASTA scores: opt: 1568,E(): 1.1e-85, (61.7% identity in 389 aa overlap); P57795|ISCS|NIFS CYSTEINE DESULFURASE (NIFS PROTEIN HOMOLOG) from Methanosarcina thermophila (404 aa), FASTA scores: opt: 1059, E(): 1.6e-55, (46.2% identity in 381 aa overlap); O54055|ISCS_RUMFL|ISCS|NIFS CYSTEINE DESULFURASE from Ruminococcus flavefaciens (396 aa), FASTA scores: opt: 973, E(): 2e-50, (43.3% identity in 381 aa overlap); P57794|NIFS_ACEDI CYSTEINE DESULFURASE from Acetobacter diazotrophicus (400 aa), FASTA scores: opt: 958, E(): 1.6e-49, (41.1% identity in 392 aa overlap); etc. Also similar to Rv1464|MTV007.11 from Mycobacterium tuberculosis. Contains PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. BELONGS TO CLASS-V OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES, NIFS/ISCS SUBFAMILY. COFACTOR: PYRIDOXAL PHOSPHATE (BY SIMILARITY). |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3340445 | 3341626 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3051c|iscS
MAYLDHAATTPMHPAAIEAMAAVQRTIGNASSLHTSGRSARRRIEEARELIADKLGARPSEVIFTAGGTESDNLAVKGIYWARRDAEPHRRRIVTTEVEHHAVLDSVNWLVEHEGAHVTWLPTAADGSVSATALREALQSHDDVALVSVMWANNEVGTILPIAEMSVVAMEFGVPMHSDAIQAVGQLPLDFGASGLSAMSVAGHKFGGPPGVGALLLRRDVTCVPLMHGGGQERDIRSGTPDVASAVGMATAAQIAVDGLEENSARLRLLRDRLVEGVLAEIDDVCLNGADDPMRLAGNAHFTFRGCEGDALLMLLDANGIECSTGSACTAGVAQPSHVLIAMGVDAASARGSLRLSLGHTSVEADVDAALEVLPGAVARARRAALAAAGASR
Bibliography
No article yet recorded
