Gene Mb3085 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namecyp136
Gene length1479 bp
IdentifierMb3085
Location 3376038 bp
Protein summary information
Molecular mass56169.6 Da
Isoelectric point7.1449
Protein length492 amino acids
Orthologs
M. tuberculosis H37RvRv3059
M. tuberculosis MTBC0mtbc0_003251
Cross-references
InterProIPR001128, IPR002403, IPR017972
UniProtKB/TrEMBLQ7TXC6
SWISS-MODELA0A1R3Y314
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE CYTOCHROME P450 136 CYP136
CommentsMb3085, cyp136, len: 492 aa. Equivalent to Rv3059,len: 492 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 492 aa overlap). Probable cyp136,cytochrome P450 136 (EC 1.14.-.-), similar to other cytochrome P450-dependent oxidases e.g. Q59990|CYP120|CYP|SLR0574 PUTATIVE CYTOCHROME P450 120 from Synechocystis sp. strain PCC 6803 (444 aa), FASTA scores: opt: 579, E(): 1.5e-29, (27.3% identity in 443 aa overlap); Q64654|CYP51|CP51_RAT CYTOCHROME P450 51 (EC 1.14.14.-) (LANOSTEROL 14-ALPHA DEMETHYLASE) from Rattus norvegicus (Rat) (503 aa), FASTA scores: opt: 549, E(): 1.4e-27, (26.2% identity in 458 aa overlap); Q9JIY3|CYP51 LANOSTEROL 14-ALPHA-DEMETHYLASE from Mus musculus (Mouse) (486 aa), FASTA scores: opt: 546, E(): 2.1e-27, (25.75% identity in 458 aa overlap). Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). BELONGS TO THE CYTOCHROME P450 FAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS33760383377516+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3085|cyp136
MATIHPPAYLLDQAKRRFTPSFNNFPGMSLVEHMLLNTKFPEKKLAEPPPGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAVLPGVAALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFHRGLMLLDFEEHMFHRRIMQEAFVRSRLAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKALTLDIASMVFMGHEPGTDHELVTKVNKAFTITTRAGNAVIRTSVPPFTWWRGLRARELLENYFTARVKERREASGNDLLTVLCQTEDDDGNRFSDADIVNHMIFLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESDRHGDGPLDIESLEQLESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNHRLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVFGQLEIKTILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR
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