Gene Mb3107c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | serine/threonine-protein kinase transcriptional regulatory protein pknk (protein kinase k) (stpk k) |
| Comments | Mb3107c, pknK, len: 1110 aa. Equivalent to Rv3080c,len: 1110 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1110 aa overlap). Probable pknK,serine/threonine protein kinase involved in transcriptional regulatory function (EC 2.7.1.-) (see citation below). Similar but shorter in N-terminus (approximatively 300 residues) to others e.g. Q48411|ACOK TRANSCRIPTIONAL REGULATORY PROTEIN OF aco ABCD operon from Klebsiella pneumoniae (921 aa), FASTA scores: opt: 886,E(): 7.6e-37, (27.75% identity in 829 aa overlap); Q9HX92|PA3921 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS) (906 aa), FASTA scores: opt: 760, E(): 1.5e-30, (29.55% identity in 822 aa overlap); Q9I2X9|PA1760 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS) (907 aa), FASTA scores: opt: 696, E(): 2.3e-27, (25.85% identity in 685 aa overlap); P06993|MALT (alias BAB37683|ECS4260 and AAG58520|MALT) POSITIVE REGULATOR OF MAL REGULON from Escherichia coli strain O157:H7 (901 aa), FASTA scores: opt: 660, E(): 1.4e-25, (29.25% identity in 530 aa overlap); Q9KNF3|VCA0011 MALT REGULATORY PROTEIN from Vibrio cholerae (BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS) (921 aa), FASTA scores: opt: 626, E(): 7.2e-24, (25.8% identity in 659 aa overlap); etc. N-terminal region similar to N-terminus of serine/threonine kinases e.g. Q9KK90|PKMA SERINE/THREONINE KINASE (SIMILAR TO THE SER/THR FAMILY OF PROTEIN KINASES) from Amycolatopsis mediterranei (589 aa), FASTA scores: opt: 545, E(): 5.7e-20, (34.45% identity in 334 aa overlap); Q9RPT5|AMK SERINE/THREONINE PROTEIN KINASE HOMOLOG (SIMILAR TO THE SER/THR FAMILY OF PROTEIN KINASES) from Amycolatopsis mediterranei (606 aa), FASTA scores: opt: 537, E(): 1.5e-19, (35.55% identity in 346 aa overlap); Q9L0I0|PKAD PROTEIN SERINE/THREONINE KINASE from Streptomyces coelicolor (599 aa), FASTA scores: opt: 520,E(): 1e-18, (36.1% identity in 324 aa overlap); etc. N-terminal part also similar to O53510|PKNL_MYCTU|Rv2176|MT2232|MTV021.09 PROBABLE SERINE/THREONINE-PROTEIN KINASE from Mycobacterium tuberculosis strain H37Rv (399 aa), FASTA scores: opt: 511, E(): 2.1e-18, (35.15% identity in 313 aa overlap). Contains PS00107 Protein kinases ATP-binding region signature and PS00017 ATP/GTP-binding site motif A (P-loop). Contains Hank's kinase subdomain. FIRST PART OF THE PROTEIN SEEMS BELONG TO THE SER/THR FAMILY OF PROTEIN KINASES, AND SECOND PARTS SEEMS BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3399203 | 3402535 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3107c|pknK
MTDVDPHATRRDLVPNIPAELLEAGFDNVEEIGRGGFGVVYRCVQPSLDRAVAVKVLSTDLDRDNLERFLREQRAMGRLSGHPHIVTVLQVGVLAGGRPFIVMPYHAKNSLETLIRRHGPLDWRETLSIGVKLAGALEAAHRVGTLHRDVKPGNILLTDYGEPQLTDFGIARIAGGFETATGVIAGSPAFTAPEVLEGASPTPASDVYSLGATLFCVLTGHAAYERRSGERVIAQFLRITSQPIPDLRKQGLPADVAAAIERAMARHPADRPATAADVGEELRDVQRRNGVSVDEMPLPVELGVERRRSPEAHAAHRHTGGGTPTVPTPPTPATKYRPSVPTGSLVTRSRLTDILRAGGRRRLILIHAPSGFGKSTLAAQWREELSRDGAAVAWLTIDNDDNNEVWFLSHLLESIRRVRPTLAESLGHVLEEHGDDAGRYVLTSLIDEIHENDDRIAVVIDDWHRVSDSRTQAALGFLLDNGCHHLQLIVTSWSRAGLPVGRLRIGDELAEIDSAALRFDTDEAAALLNDAGGLRLPRADVQALTTSTDGWAAALRLAALSLRGGGDATQLLRGLSGASDVIHEFLSENVLDTLEPELREFLLVASVTERTCGGLASALAGITNGRAMLEEAEHRGLFLQRTEDDPNWFRFHQMFADFLHRRLERGGSHRVAELHRRASAWFAENGYLHEAVDHALAAGDPARAVDLVEQDETNLPEQSKMTTLLAIVQKLPTSMVVSRARLQLAIAWANILLQRPAPATGALNRFETALGRAELPEATQADLRAEADVLRAVAEVFADRVERVDDLLAEAMSRPDTLPPRVPGTAGNTAALAAICRFEFAEVYPLLDWAAPYQEMMGPFGTVYAQCLRGMAARNRLDIVAALQNFRTAFEVGTAVGAHSHAARLAGSLLAELLYETGDLAGAGRLMDESYLLGSEGGAVDYLAARYVIGARVKAAQGDHEGAADRLSTGGDTAVQLGLPRLAARINNERIRLGIALPAAVAADLLAPRTIPRDNGIATMTAELDEDSAVRLLSAGDSADRDQACQRAGALAAAIDGTRRPLAALQAQILHIETLAATGRESDARNELAPVATKCAELGLSRLLVDAGLA
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