Gene Mb3109c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | VIRULENCE-REGULATING TRANSCRIPTIONAL REGULATOR VIRS (ARAC/XYLS FAMILY) |
| Comments | Mb3109c, virS, len: 340 aa. Equivalent to Rv3082c,len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 340 aa overlap). virS, transcriptional regulatory protein araC/xylS family, probably involved in virulence (see citation below). Similar to many transcriptional regulators araC/xylS family e.g. Q9HZ25|PA3215 PROBABLE TRANSCRIPTIONAL REGULATOR (ARAC/XYLS FAMILY) from Pseudomonas aeruginosa (337 aa),FASTA scores: opt: 379, E(): 3e-17, (30.4% identity in 306 aa overlap); Q9Z3Y6|PHBR POLYHYDROXYBUTYRATE TRANSCRIPTIONAL ACTIVATOR from Pseudomonas sp. 61-3 (379 aa), FASTA scores: opt: 336, E(): 2e-14, (26.35% identity in 334 aa overlap); P72171|ORUR|PA0831 ORNITHINE UTILIZATION TRANSCRIPTIONAL REGULATOR oruR from Pseudomonas aeruginosa (339 aa), FASTA scores: opt: 274,E(): 1.9e-10, (23.7% identity in 321 aa overlap); Q9ZFW7 VIRULENCE REGULATING HOMOLOG from Pseudomonas alcaligenes (346 aa), FASTA scores: opt: 262, E(): 1.2e-09, (24.5% identity in 339 aa overlap); etc. Also similar to O69703|Rv3736|MTV025.084 PUTATIVE REGULATORY PROTEIN (ARAC/XYLS FAMILY) from Mycobacterium tuberculosis strain H37Rv (353 aa), FASTA scores: opt: 656, E(): 3.5e-35,(36.95% identity in 333 aa overlap). Has potential helix-turn-helix motif at positions 252-273. BELONGS TO THE ARAC/XYLS FAMILY OF TRANSCRIPTIONAL REGULATORS. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3403951 | 3404973 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3109c|virS
MELGSLIRATNLWGYTDLMRELGADPLPFLRRFDIPPGIEHQEDAFMSLAGFVRMLEASAAELDCPDFGLRLARWQGLGILGPVAVIARNAATLFGGLEAIGRYLYVHSPALTLTVSSTTARSNVRFGYEVTEPGIPYPLQGYELSMANAARMIRLLGGPQARARVFSFRHAQLGTDAAYREALGCTVRFGRTWCGFEVDHRLAGRPIDHADPETKRIATKYLESQYLPSDATLSERVVGLARRLLPTGQCSAEAIADQLDMHPRTLQRRLAAEGLRCHDLIERERRAQAARYLAQPGLYLSQIAVLLGYSEQSALNRSCRCWFGMTPRQYRAYGGVSGR
Bibliography
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