Gene Mb3133 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namefprA
Gene length1371 bp
IdentifierMb3133
Location 3430555 bp
Protein summary information
Molecular mass49356.1 Da
Isoelectric point5.3771
Protein length456 amino acids
Orthologs
M. tuberculosis H37RvRv3106
M. tuberculosis MTBC0mtbc0_003302
Cross-references
InterProIPR016040, IPR021163
UniProtKB/TrEMBLQ7TX87
SWISS-MODELA0A1R3Y343
General annotation
TypeCDS
FunctionUnknown
Productnadph:adrenodoxin oxidoreductase fpra (nadph-ferredoxin reductase)
CommentsMb3133, fprA, len: 456 aa. Equivalent to Rv3106,len: 456 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 456 aa overlap). Probable fprA,NADPH:adrenodoxin oxidoreductase (EC 1.18.1.2), equivalent to O32886|MLCB1779.25|FPRA|ML0666 from Mycobacterium leprae (456 aa), FASTA scores: opt: 2505, E(): 1.2e-142,(81,05% identity in 459 aa overlap); also similar to other NADPH:adrenodoxin oxidoreductases e.g. Q9RX19|DR0496 from Deinococcus radiodurans (479 aa), FASTA scores: opt: 1331,E(): 2.6e-72, (48.9% identity in 454 aa overlap); Q9RK35|SCF15.02 from Streptomyces coelicolor (454 aa),FASTA scores: opt: 1102, E(): 1.3e-58, (41.35% identity in 462 aa overlap); P82861 from Salvelinus fontinalis (Brook trout) (498 aa), FASTA scores: opt: 827, E(): 4e-42,(41.3% identity in 460 aa overlap); Q9V3T9|ADRO_DROME from Drosophila melanogaster (Fruit fly) (466 aa), FASTA scores: opt: 790, E(): 6.3e-40, (39.45% identity in 459 aa overlap); etc. Also similar to Q10547|FPRB|Rv0886|MT0909|MTCY31.14 from Mycobacterium tuberculosis strain H37Rv (575 aa), FASTA scores: opt: 894, E(): 4.4e-46, (42.05% identity in 459 aa overlap).
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS34305553431925+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3133|fprA
MRPYYIAIVGSGPSAFFAAASLLKAADTTEDLDMAVDMLEMLPTPWGLVRSGVAPDHPKIKSISKQFEKTAEDPRFRFFGNVVVGEHVQPGELSERYDAVIYAVGAQSDRMLNIPGEDLPGSIAAVDFVGWYNAHPHFEQISPDLSGARAVVIGNGNVALDVARILLTDPDVLARTDIADHALESLRPRGIQEVVIVGRRGPLQAAFTTLELRELADLDGVDVVIDPAELDGITDEDAAAVGKVCKQNIKVLRGYADREPRPGHRRMVFRFLTSPIEIKGKRKVERIVLGRNELVSDGSGRVAAKDTGEREELPAQLVVRSVGYRGVPTPGLPFDDQSGTIPNVGGRINGSPNEYVVGWIKRGPTGVIGTNKKDAQDTVDTLIKDLGNAKEGAECKSFPEDHADQVADWLAARQPKLVTSAHWQVIDAFERAAGEPHGRPRVKLASLAELLRIGLG
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