Gene Mb3175
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE NADH DEHYDROGENASE I (CHAIN G) NUOG (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN G) |
| Comments | Mb3175, nuoG, len: 806 aa. Equivalent to Rv3151,len: 806 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 806 aa overlap). Probable nuoG, NADH dehydrogenase I, chain G (EC 1.6.5.3), similar to others e.g. Q9XAR0|NUOG_STRCO from Streptomyces coelicolor (843 aa), FASTA scores: opt: 1968 ,E(): 5.2e-107, (62.45% identity in 818 aa overlap); P56914|NUG2_RHIME from Rhizobium meliloti (853 aa), FASTA scores: opt: 964, E(): 1.6e-48, (30.6% identity in 840 aa overlap); etc. But also similarity with other proteins e.g. P77908|FDHA FORMATE DEHYDROGENASE, ALPHA SUBUNIT (EC 1.2.1.43) (FORMATE DEHYDROGENASE [NADP+]) from Moorella thermoacetica (Clostridium thermoaceticum) (893 aa), FASTA scores: opt: 928, E(): 2e-46, (28.65% identity in 865 aa overlap); and Q9UUU3|NUAM NUAM PROTEIN PRECURSOR (EC 1.6.99.3) from Yarrowia lipolytica (Candida lipolytica) (728 aa), FASTA scores: opt: 894, E(): 1.7e-44, (31.95% identity in 676 aa overlap). Equivalent to AAK47578 from Mycobacterium tuberculosis strain CDC1551 but longer 15 aa. Contains respiratory-chain NADH dehydrogenase 75 kDa subunit signature 2 (PS00642). BELONGS TO THE COMPLEX I 75 KDA SUBUNIT FAMILY. COFACTOR: MAY BIND TWO 4FE-4S CLUSTER AND ONE 2FE-2S CLUSTER. TBparse score is 0.887. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3471855 | 3474275 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3175|nuoG
MTQAADTDIRVGQPEMVTLTIDGVEISVPKGTLVIRAAELMGIQIPRFCDHPLLEPVGACRQCLVEVEGQRKPLASCTTVATDDMVVRTQLTSEIADKAQHGVMELLLINHPLDCPMCDKGGECPLQNQAMSNGRTDSRFTEAKRTFAKPINISAQVLLDRERCILCARCTRFSDQIAGDPFIDMQERGALQQVGIYADEPFESYFSGNTVQICPVGALTGTAYRFRARPFDLVSSPSVCEHCASGCAQRTDHRRGKVLRRLAGDDPEVNEEWNCDKGRWAFTYATQPDVITTPLIRDGGDPKGALVPTSWSHAMAVAAQGLAAARGRTGVLVGGRVTWEDAYAYAKFARITLGTNDIDFRARPHSAEEADFLAARIAGRHMAVSYADLESAPVVLLVGFEPEDESPIVFLRLRKAARRHRVPVYTIAPFATGGLHKMSGRLIKTVPGGEPAALDDLATGAVGDLLATPGAVIMVGERLATVPGGLSAAARLADTTGARLAWVPRRAGERGALEAGALPTLLPGGRPLADEVARAQVCAAWHIAELPAAAGRDADGILAAAADETLAALLVGGIEPADFADPDAVLAALDATGFVVSLELRHSAVTERADVVFPVAPTTQKAGAFVNWEGRYRTFEPALRGSTLQAGQSDHRVLDALADDMGVHLGVPTVEAAREELAALGIWDGKHAAGPHIAATGPTQPEAGEAILTGWRMLLDEGRLQDGEPYLAGTARTPVVRLSPDTAAEIGAADGEAVTVSTSRGSITLPCSVTDMPDRVVWLPLNSAGSTVHRQLRVTIGSIVKIGAGS
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