Gene Mb3251
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | possible iron-regulated short-chain dehydrogenase/reductase |
| Comments | Mb3251, -, len: 282 aa. Equivalent to Rv3224, len: 282 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 282 aa overlap). Probable oxidoreductase, possible short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to BAB49551|MLL2413 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (288 aa), FASTA scores: opt: 1053,E(): 6.4e-59, (57.95% identity in 276 aa overlap); Q9AB34|CC0400 SHORT CHAIN DEHYDROGENASE FAMILY PROTEIN from Caulobacter crescentus (285 aa), FASTA scores: opt: 1051, E(): 8.5e-59, (55.9% identity in 281 aa overlap); and Q9VB10|CG5590 HYPOTHETICAL PROTEIN (SIMILAR TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY) from Drosophila melanogaster (Fruit fly) (412 aa), FASTA scores: opt: 966, E(): 2.5e-53, (52.15% identity in 278 aa overlap). Similar to various proteins (principaly oxidoreductases) e.g. Q18639|C45B11.3 HYPOTHETICAL PROTEIN (SIMILAR TO THE SDR FAMILY) from Caenorhabditis elegans (293 aa), FASTA scores: opt: 921, E(): 1.2e-50, (51.3% identity in 271 aa overlap); Q9HZV5|PA2892 PROBABLE SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (274 aa), FASTA scores: opt: 847, E(): 5.1e-46, (49.25% identity in 274 aa overlap); Q9I6V0|PA0182 PROBABLE SHORT-CHAIN DEHYDROGENASE (SIMILAR TO THE SDR FAMILY) from Pseudomonas aeruginosa (250 aa), FASTA scores: opt: 333,E(): 8.3e-14, (29.8% identity in 245 aa overlap); Q9HY98|PA3511 PROBABLE SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (253 aa), FASTA scores: opt: 330,E(): 1.3e-13, (31.2% identity in 250 aa overlap); etc. Related proteins in Mycobacterium tuberculosis include MTCY02B10.14, MTCY369.14, and MTCY09F9.36. Has ATP/GTP-binding site motif A, (PS00017) near C-terminus. MAY BE BELONG TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3554450 | 3555298 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3251|Mb3251
MSLNGKTMFISGASRGIGLAIAKRAARDGANIALIAKTAEPHPKLPGTVFTAAKELEEAGGQALPIVGDIRDPDAVASAVATTVEQFGGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHMKGRENPHILTLSPPILLEKKWLRPTAYMMAKYGMTLCALGIAEEMRADGIASNTLWPRTMVATAAVQNLLGGDEAMARSRKPEVYADAAYVIVNKPATEYTGKTLLCEDVLVESGVTDLSVYDCVPGATLGVDLWVEDANPPGYLPA
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