Gene Mb3274c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | TWO COMPONENT SENSORY TRANSDUCTION TRANSCRIPTIONAL REGULATORY PROTEIN MTRA |
| Comments | Mb3274c, mtrA, len: 228 aa. Equivalent to Rv3246c,len: 228 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 228 aa overlap). mtrA, transcriptional activator, response regulator (see citations below),equivalent to Q9CCJ2|MTRA|ML0773 PUTATIVE TWO-COMPONENT RESPONSE REGULATOR from Mycobacterium leprae (228 aa),FASTA scores: opt: 1458, E(): 1.4e-85, (98.7% identity in 228 aa overlap). Also highly similar to others e.g. Q9F9J5|SCRA PUTATIVE RESPONSE REGULATOR from Streptomyces coelicolor (228 aa), FASTA scores: opt: 1141, E(): 1.9e-65, (74.9% identity in 227 aa overlap); Q9KYW8|SCE33.15c PUTATIVE TWO-COMPONENT SYSTEM RESPONSE REGULATOR from Streptomyces coelicolor (229 aa), FASTA scores: opt: 1141, E(): 1.9e-65, (74.9% identity in 227 aa overlap); Q9F868|REGX3 RESPONSE REGULATOR REGX3 from Mycobacterium smegmatis (228 aa), FASTA scores: opt: 730,E(): 2.3e-39, (50.90% identity in 222 aa overlap); etc. Relatives in Mycobacterium tuberculosis are: U01971|MTU01971_1; Q11156|RGX3_MYCTU; MTCY20G9.17, E(): 0; MTCY31.31c, E(): 3.4e-29; MTCY369.02, E(): 5.7e-28. SIMILAR TO BACTERIAL REGULATORY PROTEINS INVOLVED IN SIGNAL TRANSDUCTION. THE N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS. Experiments showed mtrA is differentially expressed in virulent and avirulent strains during growth in macrophages. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3581263 | 3581949 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3274c|mtrA
MDTMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRRNDDEPAEMLSIADVEIDVPAHKVTRNGEQISLTPLEFDLLVALARKPRQVFTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGPP
Bibliography
No article yet recorded
