Gene Mb3276c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namesahH
Gene length1488 bp
IdentifierMb3276c
Location 3582760 bp
Protein summary information
Molecular mass54337.7 Da
Isoelectric point4.8492
Protein length495 amino acids
Orthologs
M. tuberculosis H37RvRv3248c
M. tuberculosis MTBC0mtbc0_003456
Cross-references
UniProtKB/TrEMBLX2BN18, Q7TWW7
SWISS-MODELQ7TWW7
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE ADENOSYLHOMOCYSTEINASE SAHH (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE)
CommentsMb3276c, sahH, len: 495 aa. Equivalent to Rv3248c,len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 495 aa overlap). Probable sahH,adenosylhomocysteinase (EC 3.3.1.1), equivalent to Q9CCJ4|SAHH|ML0771 PUTATIVE S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE from Mycobacterium leprae (492 aa), FASTA scores: opt: 3019, E(): 1.3e-177, (91.4% identity in 489 aa overlap). Also highly similar to other adenosylhomocysteinases e.g. Q9KZM1|SAHH from Streptomyces coelicolor (485 aa), FASTA scores: opt: 2258, E(): 5.7e-131, (70.0% identity in 483 aa overlap); P51540|SAHH_TRIVA from Trichomonas vaginalis (486 aa),FASTA scores: opt: 2005, E(): 1.8e-115, (62.05% identity in 477 aa overlap); P35007|SAHH_CATRO from Catharanthus roseus (Rosy periwinkle) (Madagascar periwinkle) (485 aa),FASTA scores: opt: 1941, E(): 1.5e-111, (60.15% identity in 492 aa overlap); etc. Has S-adenosyl-L-homocysteine hydrolase signature (PS00739). BELONGS TO THE ADENOSYLHOMOCYSTEINASE FAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS35827603584247-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3276c|sahH
MTGNLVTKNSLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKIFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY
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