Gene Mb3313
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE BIFUNCTIONAL PROTEIN ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE (ALPHA CHAIN) ACCA3: BIOTIN CARBOXYLASE + BIOTIN CARBOXYL CARRIER PROTEIN (BCCP) |
| Comments | Mb3313, accA3, len: 600 aa. Equivalent to Rv3285,len: 600 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 600 aa overlap). Probable accA3,bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain (EC 6.3.4.14) (see citations below) equivalent to P46392|BCCA_MYCLE|BCCA|ML0726|B1308_C1_129 ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE ALPHA CHAIN from Mycobacterium leprae (598 aa), FASTA scores: opt: 3510,E(): 1.1e-196, (89.3% identity in 601 aa overlap). Also highly similar to other proteins e.g. P71122|ACCBC ACYL COENZYME A CARBOXYLASE from Corynebacterium glutamicum (Brevibacterium flavum) (591 aa), FASTA scores: opt: 2776,E(): 5.6e-154, (71.95% identity in 592 aa overlap); Q54119|BCPA2 BIOTIN CARBOXYLASE AND BIOTIN CARBOXYL CARRIER PROTEIN from Saccharopolyspora erythraea (Streptomyces erythraeus) (591 aa), FASTA scores: opt: 2723, E(): 6.7e-151, (70.5% identity in 590 aa overlap); Q54105|BCPA BIOTIN CARBOXYLASE AND BIOTIN CARBOXYL CARRIER PROTEIN from Saccharopolyspora erythraea (Streptomyces erythraeus) (597 aa), FASTA scores: opt: 2721, E(): 8.9e-151, (70.05% identity in 594 aa overlap); Q9EWV4|2SCK31.20 PUTATIVE ACYL-COA CARBOXYLASE COMPLEX A SUBUNIT from Streptomyces coelicolor (590 aa), FASTA scores: opt: 2626, E(): 2.9e-145, (68.25% identity in 595 aa overlap); etc. Contains PS00867 Carbamoyl-phosphate synthase subdomain signature 2, PS00188 Biotin-requiring enzymes attachment site. SIMILAR TO OTHER BIOTIN-DEPENDENT ENZYMES AND CARBAMOYL-PHOSPHATE SYNTHETASES. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3620882 | 3622684 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3313|accA3
MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFRIANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIETEWNNTIEPFTDGEPLDEDARPRQKVVVEIDGRRVEVSLPADLALSNGGGCDPVGVIRRKPKPRKRGAHTGAAASGDAVTAPMQGTVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK
Bibliography
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