Gene Mb3331c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | nad(p)h quinone reductase lpda |
| Comments | Mb3331c, lpdA, len: 471 aa. Equivalent to Rv3303c,len: 493 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 471 aa overlap). Probable lpdA,dihydrolipoamide dehydrogenase (EC 1.8.1.4), similar to other e.g. Q9EWV3|2SCK31.22c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (475 aa), FASTA scores: opt: 1420,E(): 2.4e-77, (54.9% identity in 471 aa overlap); Q9A7J2|CC1731 LIPOAMIDE DEHYDROGENASE (E3 COMPONENT,PYRUVATE DEHYDROGENASE COMPLEX) from Caulobacter crescentus (466 aa), FASTA scores: opt: 696, E(): 3.6e-34,(29.6% identity in 463 aa overlap); Q04829|LPD|DLDH_HALVO DIHYDROLIPOAMIDE DEHYDROGENASE from Halobacterium volcanii (Haloferax volcanii) (474 aa), FASTA scores: opt: 675,E(): 6.5e-33, (29.3% identity in 471 aa overlap); P50970|DLDH_ZYMMO|LPD DIHYDROLIPOAMIDE DEHYDROGENASE from Zymomonas mobilis, FASTA scores: opt: 658, E(): 6.6e-32,(30.4% identity in 464 aa overlap); etc. BELONGS TO THE PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASES CLASS-I. COFACTOR: FAD (BY SIMILARITY). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis,truncation due to a single base transversion (c-a) results in a shorter product compared to its homolog in Mycobacterium tuberculosis stain H37Rv (471 aa versus 493 aa). |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3644048 | 3645463 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3331c|lpdA
MVTRIVILGGGPAGYEAALVAATSHPETAQVTVIDCDGIGGAAVLDDCVPSKTFIASTGLRTELRRAPHLGFHIDFDDAKISLPQIHARVKTLAAAQSADITAQLLSMGVQVIAGRGELIDSTPGLARHRIKATAADGSTSEHEADVVLVATGASPRILPSAQPDGERILTWRQLYDLDALPDHLIVVGSGVTGAEFVDAYTELGVPVTVVASQDHVLPYEDADAALVLEESFAERGVRLFKNARAASVTRTGAGVLVTMTDGRTVEGSHALMTIGSVPNTSGLGLERVGIQLGRGNYLTVDRVSRTSATGIYAAGDCTGLLPLASVAAMQGRIAMYHALGEGVSPIRLRTVAATVFTRPEIAAVGVPQSVIDAGSVAARTIMLPLRTNARAKMSEMRHGFVKIFCRRSTGVVIGGVVVAPIASELILPIAVAVQNRITVNELAQTLAVYPSLSGSITEAARRLMAHDDLD
Bibliography
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