Gene Mb3409 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameamiD
Gene length1428 bp
IdentifierMb3409
Location 3742261 bp
Protein summary information
Molecular mass50645.7 Da
Isoelectric point5.7441
Protein length475 amino acids
Orthologs
M. tuberculosis H37RvRv3375
M. tuberculosis MTBC0mtbc0_003590
Cross-references
UniProtKB/TrEMBLX2BPC8, P63497
SWISS-MODELP63497
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE AMIDASE AMID (ACYLAMIDASE) (ACYLASE)
CommentsMb3409, amiD, len: 475 aa. Equivalent to Rv3375,len: 475 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 475 aa overlap). Probable amiD,amidase (EC 3.5.1.4), similar to various amidases e.g. Q53116|AMDA ENANTIOMERASE-SELECTIVE AMIDASE from Rhodococcus sp. (462 aa), FASTA scores: opt: 1036, E(): 1.6e-54, (38.6% identity in 464 aa overlap); Q9ZHK8|PZAA NICOTINAMIDASE/PYRAZINAMIDASE from Mycobacterium smegmatis (468 aa), FASTA scores: opt: 930, E(): 3.4e-48, (36.3% identity in 463 aa overlap); Q9A551|CC2613 PYRAZINAMIDASE/NICOTINAMIDASE from Caulobacter crescentus (464 aa), FASTA scores: opt: 841, E(): 7.1e-43, (39.45% identity in 469 aa overlap); O69768|AMID_PSEPU AMIDASE from Pseudomonas putida (466 aa), FASTA scores: opt: 800,E(): 2e-40, (33.6% identity in 467 aa overlap); O28325|YJ54_ARCFU|AF1954 PUTATIVE AMIDASE from Archaeoglobus fulgidu (453 aa), FASTA scores: opt: 669,E(): 1.3e-32, (30.4% identity in 467 aa overlap); etc. Also some similarity to AMIB2|Rv1263|MT1301|MTCY50.19c putative amidase from Mycobacterium tuberculosis (462 aa),(31.5% identity in 466 aa overlap). SEEMS BELONG TO THE AMIDASE FAMILY.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS37422613743688+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3409|amiD
MTDADSAVPPRLDEDAISKLELTEVADLIRTRQLTSAEVTESTLRRIERLDPQLKSYAFVMPETALAAARAADADIARGHYEGVLHGVPIGVKDLCYTVDAPTAAGTTIFRDFRPAYDATVVARLRAAGAVIIGKLAMTEGAYLGYHPSLPTPVNPWDPTAWAGVSSSGCGVATAAGLCFGSIGSDTGGSIRFPTSMCGVTGIKPTWGRVSRHGVVELAASYDHVGPITRSAHDAAVLLSVIAGSDIHDPSCSAEPVPDYAADLALTRIPRVGVDWSQTTSFDEDTTAMLADVVKTLDDIGWPVIDVKLPALAPMVAAFGKMRAVETAIAHADTYPARADEYGPIMRAMIDAGHRLAAVEYQTLTERRLEFTRSLRRVFHDVDILLMPSAGIASPTLETMRGLGQDPELTARLAMPTAPFNVSGNPAICLPAGTTARGTPLGVQFIGREFDEHLLVRAGHAFQQVTGYHRRRPPV
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