Gene Mb3411c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | halimadienyl diphosphate synthase |
| Comments | Mb3411c, -, len: 483 aa. Similar to the 5' end of Rv3377c, len: 501 aa, from Mycobacterium tuberculosis strain H37Rv, (89.9% identity in 464 aa overlap). Possible cyclase; similarity with various proteins, notably cyclases involved in steroid biosynthesis in plants and bacteria e.g. BAB52679|MLR6369 from Rhizobium loti (Mesorhizobium loti) (516 aa), FASTA scores: opt: 533,E(): 5.6e-27, (30.45% identity in 522 aa overlap); Q9ZTN8 COPALYL DIPHOSPHATE SYNTHASE 1 from Cucurbita maxima (Pumpkin) (Winter squash) (823 aa), FASTA scores: opt: 484, E(): 1.2e-23, (28.35% identity in 388 aa overlap); Q38710|AC22 ABIETADIENE CYCLASE from Abies grandis (868 aa), FASTA scores: opt: 382, E(): 5.2e-17, (25.55% identity in 462 aa overlap); Q41771|AN1 KAURENE SYNTHASE A from Zea mays (Maize) (823 aa), FASTA scores: opt: 377,E(): 1.1e-16, (29.75% identity in 390 aa overlap); Q9AJE4 DITERPENE CYCLASE-1 from Kitasatospora griseola (Streptomyces griseolosporeus) (499 aa), FASTA scores: opt: 336, E(): 3.2e-14, (27.5% identity in 513 aa overlap); Q9SAU6 E-ALPHA-BISABOLENE SYNTHASE (FRAGMENT) from Abies grandis (782 aa), FASTA scores: opt: 317, E(): 7.8e-13, (25.25% identity in 479 aa overlap); etc. Note that this and the upstream ORF MTV004.36c have a significantly lower GC bias than the rest of the genome. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a 4 bp to 3 bp substitution (caat-aac) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3744541 | 3745992 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3411c|Mb3411c
METFRTLLAKAALGNGISSTAYDTAWVAKLGQLDDELSDLALNWLCERQLPDGSWGAEFPFCYEDRLLSTLAAMISLTSNKHRRRRAAQVEKGLLALKNLTSGAFEGPQLDIKDATVGFELIAPTLMAEAARLGLAICHEESILGELVGVREQKLRKLGGSKINKHITAAFSVELAGQDGVGMLDVDNLQETNGSVKYSPSASAYFALHVKPGDKRALAYISSIIQAGDGGAPAFYQAEIFEIVWSLWNLSRTDIDLSDPEIVRTYLPYLDHVEQHWVRGRGVGWTGNSTLEDCDTTSVAYDVLSKFGRSPDIGAVLQFEDADWFRTYFHEVGPSISTNVHVLGALKQAGYDKCHPRVRKVLEFIRSSKEPGRFCWRDKWHRSAYYTTAHLICAASNYDDALCSDAVGGFLIRRGPMARGDFSTAKRLRKRQHIAFKLWRIGRGTAAHPCRRRSVARVGGYRNTANRHTRRCGLPRHFTARRR
Bibliography
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