Gene Mb3415c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | POSSIBLE POLYPRENYL SYNTHETASE IDSB (POLYPRENYL TRANSFERASE) (POLYPRENYL DIPHOSPHATE SYNTHASE) |
| Comments | Mb3415c, idsB, len: 350 aa. Equivalent to Rv3383c,len: 350 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 350 aa overlap). Possible idsB,polyprenyl transferase (polyprenyl diphosphate synthase) (EC 2.5.1.-), similar to many prenyltransferases involved in lipid biosynthesis e.g. Q9RGW1|GTR GERANYL TRANSFERASE from Streptomyces coelicolor (386 aa), FASTA scores: opt: 908, E(): 3.7e-50, (48.8/% identity in 334 aa overlap); Q9KWG0|GGDPS GERANYL GERANYL DIPHOSPHATE SYNTHASE from Kitasatospora griseola (Streptomyces griseolosporeus) (348 aa), FASTA scores: opt: 801, E(): 2e-43, (41.5% identity in 347 aa overlap); Q9X7V8|SC6A5.12 PUTATIVE POLYPRENYL SYNTHETASE from Streptomyces coelicolor (378 aa), FASTA scores: opt: 779, E(): 5.3e-42, (44.45% identity in 324 aa overlap); Q9S5E9 FARNESYL, GERANYLGERANYL,GERANYLFARNESYL, HEXAPRENYL, HEPTAPRENYL DIPHOSPHATE SYNTHASE (SELF-HEPPS) from Synechococcus elongatus (324 aa), FASTA scores: opt: 563, E(): 2.3e-28, (39.85% identity in 241 aa overlap) (see citation below); O26156|IDSA_METTH|MTH50 BIFUNCTIONAL SHORT CHAIN ISOPRENYL DIPHOSPHATE SYNTHASE [INCLUDES: FARNESYL PYROPHOSPHATE SYNTHETASE (EC 2.5.1.1) (FPP SYNTHETASE) (DIMETHYLALLYLTRANSFERASE) AND GERANYLTRANSTRANSFERASE (EC 2.5.1.10)] from Methanobacterium thermoautotrophicum (325 aa), FASTA scores: opt: 540, E(): 6.5e-27, (35.75% identity in 319 aa overlap); P95999|GGPP_SULSO|GDS|GDS-1|SSO0061|C05010|C05_049 GERANYLGERANYL PYROPHOSPHATE SYNTHETASE (GGPP SYNTHETASE) (GGPS) [INCLUDES: DIMETHYLALLYLTRANSFERASE (EC 2.5.1.1)AND GERANYLTRANSTRANSFERASE (EC 2.5.1.10) AND FARNESYLTRANSTRANSFERASE (EC 2.5.1.29)] from Sulfolobus solfataricus (332 aa), FASTA scores: opt: 511, E(): 4.5e-25 (36.9% identity in 244 aa overlap); etc. Also similar to Q50727|GGPP_MYCTU|Rv3398c|MT3506|MTCY78.30 PROBABLE MULTIFUNCTIONAL GERANYLGERANYL PYROPHOSPHATE SYNTHETASE [INCLUDES: DIMETHYLALLYLTRANSFERASE (EC 2.5.1.1); GERANYLTRANSTRANSFERASE (EC 2.5.1.10); FARNESYLTRANSTRANSFERASE (EC 2.5.1.29)] from Mycobacterium tuberculosis (359 aa), FASTA scores: opt: 687, E(): 3.4e-36, (39.1% identity in 325 aa overlap). Contains PS00723 Polyprenyl synthetases signature 1. BELONGS TO THE FPP/GGPP SYNTHETASES FAMILY. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3749720 | 3750772 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3415c|idsB
MGGVLTLDAAFLGSVPADLGKALLERARADCGPVLHRAIESMREPLATMAGYHLGWWNADRSTAAGSSGKYFRAALVYAAAAACGGDVGDATPVSAAVELVHNFTLLHDDVMDGDATRRGRPTVWSVWGVGGAILLGDALHATAVRILTGLTDECVAVRAIRRLQMSCLDLCIGQFEDCLLEGQPEVTVDDYLRMAAGKTAALTGCCCALGALVANADDATIAALERFGHELGLAFQCVDDLIGIWGDPGVTGKPVGNDLARRKATLPVVAALNSRSEAATELAALYQAPAAMTASDVERATALVKVAGGGHVAQRCADERIQAAIAALPDAVRSPDLIALSQLICRREC
Bibliography
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