Gene Mb3421c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | probable 3-hydroxyacyl-thioester dehydratase htdy |
| Comments | Mb3421c, -, len: 290 aa. Equivalent to Rv3389c,len: 290 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 290 aa overlap). Possible dehydrogenase (EC 1.-.-.-), similar to parts of several bacterial dehydrogenases and eukaryotic short-chain dehydrogenases involved in steroid biosynthesis e.g. Q9UVH9|FOX2 FOX2 PROTEIN (a multifunctional protein of the peroxisomal beta-oxidation) (SIMILAR TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY) from Glomus mosseae (1015 aa), FASTA scores: opt: 649, E(): 7.5e-33,(40.9% identity in 269 aa overlap); Q9L009|SCC30.12c PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (333 aa), FASTA scores: opt: 602, E(): 2.7e-30, (40.35% identity in 305 aa overlap); AAH03098 HYDROXYSTEROID (17-BETA) DEHYDROGENASE 4 from Homo sapiens (Human) (736 aa), FASTA scores: opt: 592, E(): 2.1e-29, (41.55% identity in 272 aa overlap); P51659|DHB4_HUMAN ESTRADIOL 17 BETA-DEHYDROGENASE 4 from Homo sapiens (Human) (736 aa), FASTA scores: opt: 592, E(): 2.1e-29, (41.55% identity in 272 aa overlap); Q19058|E04F6.3 HYDRATASE-DEHYDROGENASE-EPIMERASE from Caenorhabditis elegans (298 aa), FASTA scores: opt: 573, E(): 1.6e-28,(41.0% identity in 266 aa overlap); O42484 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE IV from Gallus gallus (Chicken) (735 aa), FASTA scores: opt: 573, E(): 3.2e-28, (39.8% identity in 279 aa overlap); etc. And also similar in part to Q9LBK1|PHAJ2|PA1018 (R)-SPECIFIC ENOYL-COA HYDRATASE from Pseudomonas aeruginosa (288 aa),FASTA scores: opt: 601, E(): 2.7e-30, (40.5% identity in 294 aa overlap). And similar to P71863|UFAA2|Rv3538|MTCY03C7.18c HYPOTHETICAL 30.2 KDA PROTEIN from Mycobacterium tuberculosis (286 aa), FASTA scores: opt: 609, E(): 8.7e-31, (39.65% identity in 285 aa overlap). HAS SOME SIMILARITY TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3756256 | 3757128 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3421c|htdy
MAIDPNSIGAVTEPMLFEWTDRDTLLYAIGVGAGTGDLAFTTENSHGIDQQVLPTYAVICCPAFGAAAKVGTFNPAALLHGSQGIRLHAPLPAAGKLSVVTEVADIQDKGEGKNAIVVLRGRGCDPESGSLVAETLTTLVLRGQGGFGGARGERPAAPEFPDRHPDARIDMLTREDQALIYRLSGDRNPLHSDPWFATQLAGFPKPILHGLCTYGVAGRALVAELGGGVAANITSIAARFTKPVFPGETLSTVIWRTEPGRAVFRTEVAGSDGAEARVVLDDGAVEYVAG
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