Gene Mb3429c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE GMP SYNTHASE [GLUTAMINE-HYDROLYZING] GUAA (GLUTAMINE AMIDOTRANSFERASE) (GMP SYNTHETASE) |
| Comments | Mb3429c, guaA, len: 525 aa. Equivalent to Rv3396c,len: 525 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 525 aa overlap). Probable guaA, gmp synthase (EC 6.3.5.2) (see citation below), equivalent to P46810|GUAA_MYCLE|ML0395|B1620_C2_205 GMP SYNTHASE [GLUTAMINE-HYDROLYZING] from Mycobacterium leprae (529 aa), FASTA scores: opt: 2992, E(): 8.5e-168, (86.85% identity in 525 aa overlap). Also highly similar to others e.g. O52831|GUAA_CORAM from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (524 aa), FASTA scores: opt: 2636, E(): 5.9e-147, (76.2% identity in 521 aa overlap); Q9L0H2|GUAA_STRCO from Streptomyces coelicolor (526 aa),FASTA scores: opt: 2451, E(): 4.1e-136, (71.55% identity in 513 aa overlap); Q9KF78|GUAA_BACHD from Bacillus Halodurans (513 aa), FASTA scores: opt: 1819, E(): 4.1e-99, (52.55% identity in 510 aa overlap); etc. Contains PS00442 Glutamine amidotransferases class-I active site. BELONGS TO THE TYPE-1 GLUTAMINE AMIDOTRANSFERASE FAMILY IN THE N-TERMINAL SECTION. AND BELONGS TO THE GMP SYNTHASE FAMILY IN THE C-TERMINAL SECTION. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3764838 | 3766415 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3429c|guaA
MVQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTASIEEIRARQPVALVLSGGPASVYADGAPKLDPALLDLGVPVLGICYGFQAMAQALGGIVAHTGTREYGRTELKVLGGKLHSDLPEVQPVWMSHGDAVTAAPDGFDVVASSAGAPVAAFEAFDRRLAGVQYHPEVMHTPHGQQVLSRFLHDFAGLGAQWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAAETFLEALSGVSAPEGKRKIIGRQFIRAFEGAVRDVLDGKTAEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGLPEEIVARQPFPGPGLGIRIVGEVTAKRLDTLRHADSIVREELTAAGLDNQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEVLERISTRITNEVAEVNRVVLDITSKPPATIEWE
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